配偶间幽门螺杆菌感染的调查研究  

Investigation of Helicobacter pylori transmission between spouses

作　　者：周晴接 陈玲淑 潘杰 Qing-Jie Zhou;Ling-Shu Chen;Jie Pan(Department of Gastroenterology,Wenzhou Central Hospital,Wenzhou 325000,Zhejiang Province,China)

机构地区：[1]温州市中心医院消化内科,浙江省温州市325000

出　　处：《世界华人消化杂志》2021年第5期231-235,共5页World Chinese Journal of Digestology

摘　　要：背景幽门螺杆菌(Helicobacter pylori,H.pylori)的主要传播途径为口-口或粪-口传播,而我国传统的合餐制饮食习惯可能造成交叉感染风险增加和家庭内聚集现象,配偶作为家庭内接触最密切的人,也很可能存在H.pylori的互相传播现象.目的调查研究配偶间H.pylori的感染状况,探讨配偶间相互感染的可能性.方法选取2018-10/2019-04间配偶双方都在我院行13C尿素呼气试验检查的受试者,根据配偶中先行13C尿素呼气试验检查者的检测结果,将阳性者的配偶纳入H.pylori阳性配偶组,阴性者的配偶纳入H.pylori阴性配偶组,对两组受试者的H.pylori感染情况进行统计学分析.结果共有134例受试者纳入本研究,其中,H.pylori阳性配偶组91例,H.pylori阴性配偶组43例;H.pylori阳性配偶组受试者的H.pylori感染率为64.84%(59/91),H.pylori阴性配偶组受试者的H.pylori感染率为39.53%(17/43),H.pylori阳性配偶组明显高于H.pylori阴性配偶组(P<0.05),危险因素OR值为2.82,95%可信区间CI为1.34-5.96.对婚龄进行分层分析,H.pylori阳性配偶组不同婚龄阶段的H.pylori感染率均高于H.pylori阴性配偶组,危险因素OR值均大于1,且危险因素随着婚龄的增加有逐渐增加的趋势.结论H.pylori感染存在家庭聚集现象,拥有H.pylori阳性的配偶是H.pylori感染的危险因素,且这种风险可能随婚龄的增加而增加.在临床诊治过程中,应建议配偶双方均应该接受H.pylori的检测与治疗.BACKGROUND The main transmission route of Helicobacter pylori(H.pylori)is oral-oral or fecal-oral transmission,while the traditional eating habits in China may lead to an increased risk of cross-infection and intra-family aggregation.As the closest contact within the family,spouses are also likely to have a H.pylori cross-infection.AIM To investigate the status and possibility of H.pylori transmission between spouses.METHODS The spouses who underwent the 13C urea breath test at our hospital between October 2018 to April 2019 were selected in this study.According to the results of the 13C urea breath test,the spouses of the positive subjects were included in an observation group,and the spouses of the negative subjects were included in a control group.RESULTS A total of 134 spouses were included in this study,of which 91 were in the observation group and 43 in the control group.The incidence of H.pylori infection in the observation group was significantly higher than that of the control group[64.84%(59/91)vs 39.53%(17/43);odds ratio(OR)=2.82,95%confidence interval:1.34-5.96,P<0.05].The incidence of H.pylori infection in the observation group was higher than that of the control group at each different stage of marriage age(OR>1).The incidence of H.pylori infection increased with the age of marriage.CONCLUSION There is a certain familial aggregation of H.pylori infection.Having a H.pylori positive spouse is a risk factor for H.pylori infection and the risk may increase with the age of marriage.Both spouses should be advised to undergo H.pylori testing and treatment during clinical diagnosis and treatment.

关 键 词：幽门螺杆菌感染 配偶 婚龄 

分 类 号：R573[医药卫生—消化系统]