改良电休克联合碳酸锂治疗双相抑郁发作患者的效果  

Effects of modified electro-convulsive therapy combined with Lithium carbonate in treatment of patients with bipolar depression

作　　者：张秋云 ZHANG Qiuyun(Eighth Ward of Department of Psychiatry of Second People’s Hospital of Shangqiu City,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市第二人民医院精神科八病区,河南商丘476000

出　　处：《中国民康医学》2021年第4期79-80,83,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察改良电休克联合碳酸锂治疗双相抑郁发作患者的效果。方法:选取90例双相抑郁发作患者作为研究对象,根据随机数字表法分为对照组和观察组各45例。对照组采用碳酸锂治疗,观察组在对照组基础上加用改良电休克治疗。比较两组治疗前后简易精神状态评价量表(MMSE)评分、氧化应激指标[超氧化物歧化酶(SOD)、过氧化氢酶(CAT)]水平和不良反应发生率。结果:治疗后,两组MMSE评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组SOD、CAT水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:改良电休克联合碳酸锂治疗双相抑郁发作患者可提高认知功能评分和氧化应激指标水平,其效果优于单用碳酸锂。Objective:To observe effects of modified electro-convulsive therapy combined with Lithium carbonate in treatment of patients with bipolar depression.Methods:90 patients with bipolar depression were selected as the research objects,and were divided into control group and observation group according to the random number table method,45 cases in each group.The control group was treated with Lithium carbonate,while the observation group was treated with modified electro-convulsive therapy on the basis of that of the control group.The Minimental state examination(MMSE)score,oxidative stress indicator[superoxide dismutase(SOD),catalase(CAT)]levels and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the MMSE scores of the two groups were higher than those before the treatment;that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).After treatment,the levels of SOD and CAT in the two groups were higher than those before the treatment;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Modified electro-convulsive therapy combined with Lithium carbonate can improve the cognitive function scores and the oxidative stress index levels in the patients with bipolar depression.Moreover,it is superior to single Lithium carbonate.

关 键 词：双相抑郁症 改良电休克 碳酸锂 认知功能 氧化应激 

分 类 号：R749.4[医药卫生—神经病学与精神病学]