左乙拉西坦和丙戊酸钠单药治疗青少年肌阵挛癫痫的疗效比较  

Comparison of the Efficacy of Levetiracetam and Valproate Sodium in the treatment of juvenile myoclonic Epilepsy

作　　者：肖彩霞 XIAO Caixia(Neurology,Anyang People's Hospital,Anyang Henan 455000,China)

机构地区：[1]安阳市人民医院神经内科,河南安阳455000

出　　处：《临床研究》2021年第4期35-36,共2页Clinical Research

摘　　要：目的探究左乙拉西坦与丙戊酸钠对青少年肌阵挛癫痫治疗效果。方法选取安阳市人民医院2014年4月至2019年4月收治的70例青少年肌阵挛癫痫患者,按照入院顺序随机分为参照组与观察组。参照组给予左乙拉西坦治疗,观察组给予丙戊酸钠治疗,对比两组治疗效果及不良反应情况。结果两组治疗有效率基本相当,差异无统计学意义(P>0.05)。观察组治疗不良反应总发生率(8.57%)显著低于参照组(31.43%),差异有统计学意义(P<0.05)。结论经研究结果显示,左乙拉西坦和丙戊酸钠对青少年肌阵挛癫痫治疗的药效基本相同,但左乙拉西坦的不良反应发生率要远远低于丙戊酸钠,应该将左乙拉西坦作为青少年肌阵挛癫痫治疗的首选药物。Objective To investigate the efficacy of sodium levetiracetam and valproate in the treatment of juvenile myoclonic epilepsy.Methods A total of 70 patients with myoclonic epilepsy admitted to Anyang People’s Hospital from April 2014 to April 2019 were randomly divided into two groups.The control group was treated with Levetiracetam and the observation group was treated with valproate.The therapeutic effects and adverse reactions of the two groups were compared.Results The effective rates of the two groups were basically the same,there was no significant difference between the two groups(P>0.05).The total incidence of adverse reactions in the observation group(8.57%)was significantly lower than that in the control group(31.43%)(P<0.05).Conclusion The results show that levetiracetam and valproate have similar efficacy in the treatment of juvenile myoclonic epilepsy,but the incidence of adverse reactions of Levetiracetam is much lower than that of valproate,levetiracetam should be the drug of choice for the treatment of myoclonic epilepsy in adolescents.

关 键 词：左乙拉西坦 丙戊酸钠 青少年肌阵挛癫痫 治疗效果 

分 类 号：R742.1[医药卫生—神经病学与精神病学]