血清自身抗体及生化指标联合检测在诊断自身免疫性肝炎中的应用价值  

Application of serum autoantibodies and biochemical indexes in the diagno sis of autoimmune hepatitis

作　　者：张霜燕 ZHANG Shuangyan(Department of Clinical Laboratory,Nujiang People’s Hospital,Nujiang 673100,Yunnan,China)

机构地区：[1]怒江州人民医院检验科,云南怒江673100

出　　处：《当代医药论丛》2021年第6期129-130,共2页

摘　　要：目的:探讨血清自身抗体及生化指标联合检测在诊断自身免疫性肝炎中的应用价值。方法:选取怒江州人民医院于2018年3月至2019年4月期间收治的70例自身免疫性肝炎患者、70例病毒性肝炎患者和同期在该院进行体检的70例健康体检者作为研究对象。将其中70例自身免疫性肝炎患者作为自身免疫性肝炎组,将其中70例病毒性肝炎患者作为病毒性肝炎组,将其中70例健康体检者作为对照组。对三组人员均进行血清自身抗体及生化指标联合检测,然后对比其各项血清自身抗体及生化指标的水平。结果:1)与对照组体检者相比,自身免疫性肝炎组患者血清碱性磷酸酶、谷草转氨酶、谷氨酸氨基转移酶的水平均较高,P<0.05。与自身免疫性肝炎组患者相比,病毒性肝炎组患者血清碱性磷酸酶、谷草转氨酶的水平均较高,其血清谷氨酸氨基转移酶的水平较低,P<0.05。2)与对照组体检者和病毒性肝炎组患者相比,自身免疫性肝炎组患者血清抗核抗体、抗平滑肌抗体、抗线粒体抗体的阳性率均较高,P<0.05。结论:血清自身抗体及生化指标联合检测在诊断自身免疫性肝炎中的应用价值较高。Objective:To explore the value of combined detection of serum autoantibodies and biochemical indexes in the diagnosis of autoimmune hepatitis.METHODS:A total of 70 patients with autoimmune hepatitis,70 patients with viral hepatitis and 70 healthy subjects who underwent physical examination in Nujiang People’s Hospital during the same period from March 2018 to April 2019 were selected as subjects.Among them,70 patients with autoimmune hepatitis were selected as the autoimmune hepatitis group,70 patients with viral hepatitis were selected as the viral hepatitis group,and 70 healthy subjects were selected as the control group.Serum autoantibodies and biochemical indexes were detected in all the three groups,and then the levels of serum autoantibodies and biochemical indexes were compared.Results:1)Compared with the control group,the levels of serum alkaline phosphatase,glutamic-oxalacetic transaminase and glutamate aminotransferase in the autoimmune hepatitis group were higher(P<0.05).Compared with the autoimmune hepatitis group,the levels of serum alkaline phosphatase and glutamate-oxalacetic transaminase were higher in the viral hepatitis group,while the level of serum glutamate aminotransferase was lower(P<0.05).2)Compared with the control group and the viral hepatitis group,the positive rates of serum anti-nuclear antibody,anti-smooth muscle antibody and anti-mitochondrial antibody in the autoimmune hepatitis group were higher(P<0.05).Conclusion:The combined detection of serum autoantibodies and biochemical indexes is of high application value in the diagnosis of autoimmune hepatitis.

关 键 词：自身抗体 生化指标 自身免疫性肝炎 

分 类 号：R575.1[医药卫生—消化系统]