不同表面处理和设计的人工晶状体生物相容性的实验研究  

An experimental study on the biocompatibility of intraocular lenses with different surface modelings and designs

作　　者：王丝雨 石栋[1] 陆博[1] 韩琳 马立威[1,2] WANG Siyu;SHI Dong;LU Bo;HAN Lin;MA Liwei(Department of Ophthalmology,The Fourth Affiliated Hospital of China Medical University,Eye Hospital of China Medical University,Key Lens Laboratory of Liaoning Province,Shenyang 110005,China;Department of Ophthalmology,Shenyang Aier Excellence Eye Hospital,Aier School of Ophthalmology,Central South University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第四医院眼科,中国医科大学眼科医院,辽宁省晶状体学重点实验室,沈阳110005 [2]沈阳爱尔卓越眼科医院眼科,中南大学爱尔眼科学院,沈阳110001

出　　处：《中国医科大学学报》2021年第3期214-219,共6页Journal of China Medical University

基　　金：国家自然科学基金(81600777)。

摘　　要：目的比较2种不同表面处理和设计的人工晶状体(IOL)植入兔眼后的生物相容性。方法取10只新西兰白兔(20眼)行晶状体超声乳化吸除联合IOL植入术,每只新西兰白兔随机选择左右眼分别植入不同的IOL,植入经紫外线/臭氧后表面处理、袢表面磨砂化处理的HOYA Vivinex XY1 IOL为A组,植入经聚乙二醇全表面处理、袢表面光滑的AMO Tecnis PCB00 IOL为B组。比较术后1、7、14、28 d前房闪辉评分、晶状体后囊膜混浊评分及IOL旋转角度,术后28 d HE染色观察后囊膜晶状体上皮细胞增殖移行情况。结果术后1 d、7 d,A组平均前房闪辉评分大于B组,差异有统计学意义(P<0.05)。术后7 d、14 d、28 d,A组平均后囊膜混浊评分小于B组,差异有统计学意义(P<0.05)。术后1 d、7 d、14 d、28 d,A组IOL平均旋转角度小于B组,差异有统计学意义(P<0.05)。术后28 d HE染色显示,A组后囊膜表面仅见散在分布的单个或簇状晶状体上皮细胞,B组可见排列密集的单层或双层晶状体上皮细胞。结论经聚乙二醇全表面处理的IOL能够排斥炎症细胞的吸附,减轻术后炎症反应,葡萄膜生物相容性较好。经紫外线/臭氧后表面处理的IOL能够增加表面的黏附力,抑制晶状体上皮细胞的增殖与迁移,延缓并减轻后囊膜混浊的发生,囊膜生物相容性较好。IOL袢经磨砂化处理,可以增加袢与囊袋间的摩擦力,IOL囊袋内旋转稳定性较好。Objective To compare the biocompatibility of intraocular lenses(IOLs)with different surface modelings and designs implanted in rabbits.Methods Ten New Zealand white rabbits(20 eyes)were treated with phacoemulsification combined with IOL implantation.Group A received HOYA Vivinex XY1 IOL,while group B received AMO Tecnis PCB00 IOL.Anterior chamber flare score,posterior capsule opacification(PCO)score,and IOL rotation angle were observed 1,7,14,and 28 days after surgery.HE staining was performed to observe the proliferation of lens epithelial cells(LECs)on the posterior capsule.Results The anterior chamber flare score of group A was greater than that of group B 1 and 7 days after surgery(P<0.05).The PCO score of group A was lower than that of group B at 7,14,and 28 days(P<0.05).The average IOL rotation angle of group A was smaller than that of group B(P<0.05).HE staining showed single or clustered LECs on the posterior capsule surface of group A,while single or double layers was observed in group B.Conclusion The IOL with full surface modeling with polyethylene glycol can reduce inflammatory reaction with good uveal biocompatibility.The IOL with back surface modeling with UV/O3 can inhibit the proliferation of LECs with good capsule biocompatibility.The IOL with a textured-rough haptic surface can increase friction,and has good rotational stability in the capsule.

关 键 词：人工晶状体 生物相容性 葡萄膜生物相容性 囊膜生物相容性 旋转稳定性 

分 类 号：R776.1[医药卫生—眼科]