pH-responsive superstructures prepared via the assembly of Fe_(3)O_(4) amphipathic Janus nanoparticles  

作　　者：Shuang Cai Bin Luo Xiaohui Zhan Xiaoxi Zhou Fang Lan Qiangying Yi Yao Wu 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,Sichuan 610064,P.R.China

出　　处：《Regenerative Biomaterials》2018年第5期251-259,共9页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC,21571134,31771037);the National Key Research and Development Program of China(2016YFC1102701);the Project in the Science and Technology Support Program of Sichuan Province(18ZDYF0823);the Project of Huimin Technology Research and Development of Chengdu(2015-HM01-00379-SF).

摘　　要：The strategy of using Fe_(3)O_(4) amphiphilic Janus nanoparticles(Fe_(3)O_(4)@AJNPs)bearing b-cyclodextrin(b-CD)and aminopyridine(APD)functionalized polymethyl methacrylate(PGMA)to construct pH-stimuli responsive co-assemblies through host-guest interactions between b-CD and APD was proposed.The spherical co-assemblies with an average diameter about 210nm were excellent magnetic responsive and quite stable even up to 2 months in deionized water.The pH-liable capability of these co-assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion complexes.The disassembly process was monitored by SEM,TEM,DLS and fluorescent molecules probe.After disassembly of the co-assemblies caused by protonation of nitrogens in APD,hydrophobic PGMA-APD lacking of interactions with the Fe_(3)O_(4)@AJNPs chains was precipitated,and the remained Fe_(3)O_(4)@AJNPs turned to re-assemble to selfassemblies.Besides,the recyclable Fe_(3)O_(4)@APJNs could reassembly with additional PGMA-APD to build co-assemblies with a uniform morphology for several times.These pH-sensitive co-assemblies with high stability,good magnetic responsiveness and cytocompatibility could be used as pH-responsive vehicles within which to encapsulate drugs for subsequent controlled release.

关 键 词：Janus Fe3O4 nanoparticles Co-assembly PH-SENSITIVE Controlled release 

分 类 号：O63[理学—高分子化学]