303例闭经患者的病因学分析  

Etiological analysis of 303 patients with amenorrhea

作　　者：李凌川[1] 袁涛[1] LI Lingchuan;YUAN Tao(Department of Gynecology,the First People's Hospital of Yunnan Province,Kunming Yunnan 650032,P.R.China)

机构地区：[1]云南省第一人民医院妇科,云南昆明650032

出　　处：《中国计划生育和妇产科》2021年第3期48-51,55,共5页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的分析统计女性闭经的病因。方法收集2016年1月至2019年6月云南省第一人民医院妇科门诊闭经患者303例,通过病史、查体、抽血查性激素六项、甲状腺功能、空腹血糖等指标、影像学评估及对原发性闭经患者行染色体检查,确定闭经原因并进行统计分析。结果303例患者中,原发性闭经36例(11.89%),继发性闭经267例(88.11%)。导致原发性闭经最常见的疾病为苗勒管发育不全综合征(Mayer-Rokitansky-Kuster-Hauser syndrome,MRKH综合征),36例患者中有7例是MRKH综合征患者,多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是次要原因,有5例患者为PCOS。在继发性闭经中,Asherman综合征和PCOS是最主要的致病原因,分别占29.96%和29.59%。36例原发性闭经患者中,正常核型46,XX患者24例,占原发性闭经患者总数的66.67%。结论闭经患者最常见病因是PCOS和Asherman综合征。Objective Analyze the causes of female amenorrhea.Methods A total of 303 amenorrhea patients who attended the Gynecological Clinic of the First People's Hospital of Yunnan Province from January 2016 to June 2019 were collected.The six sex hormones,thyroid function,fasting blood glucose and other indicators were checked through medical history,physical examination,and blood sampling,as well as imaging evaluation.And performed chromosome examination on patients with primary amenorrhea to determine the cause of amenorrhea and performed statistical analysis.Results Among the 303 patients,36 cases(11.89%)were primary amenorrhea,and 267 cases(88.11%)were secondary amenorrhea.The most common disease that causes primary amenorrhea was Mullerian duct hypoplasia syndrome(Mayer-Rokitansky-Kuster-Hauser syndrome,MRKH syndrome),7 out of 36 patients were patients with MRKH syndrome,polycystic ovary syndrome(PCOS)was the secondary cause,and 5 patients were PCOS.In secondary amenorrhea,Asherman syndrome and PCOS were the main causes,accounting for 29.96%and 29.59%,respectively.Among 36 patients with primary amenorrhea,24 patients with normal karyotype 46,XX,accounting for 66.67%of the total number of patients with primary amenorrhea.Conclusion The most common causes of amenorrhea are PCOS and Asherman syndrome.

关 键 词：原发性闭经 继发性闭经 染色体检查 ASHERMAN综合征 PCOS 

分 类 号：R711.51[医药卫生—妇产科学]