Clinical observations of osteoporotic vertebral compression fractures by using mineralized collagen modified polymethylmethacrylate bone cement  

作　　者：XiWang Jian-Ming Kou Yang Yue An-Ze Shao Xue-Jun Jia Jian-Wen Hou Chong Gao Zhi-Ye Qiu Xiu-Mei Wang Xi-Sheng Weng 

机构地区：[1]Department of Orthopedics,The Second People’s Hospital of Lianyungang,No.41 Hailian East Road,Haizhou District,Lianyungang 222000,China [2]Institute for Regenerative Medicine and Biomimetic Materials,Tsinghua University,Haidian District,Beijing 100084,China [3]Department of Orthopaedics,Peking Union Medical College Hospital,No.1 Shuaifuyuan,Dongcheng District,Beijing 100730,China

出　　处：《Regenerative Biomaterials》2017年第2期105-109,共5页再生生物材料（英文版）

基　　金：This work was in part supported by the Lianyungang science and technology development plan(SH1412);the National Natural Science Foundation of China(51402167).

摘　　要：To investigate the clinical outcomes of the treatment of osteoporotic vertebral compression fractures(OVCFs)by using mineralized collagen(MC)modified polymethylmethacrylate(PMMA)bone cement.52 cases(52 vertebras)who sustained OVCF treated with MC modified PMMA bone cement from July 2014 to December 2015 were reviewed retrospectively.All the cases(52 patients,52 vertebras)included 8 males and 44 females with an average age of 74.83(ranging from 57-to 90-years old).The visual analogue scale(VAS),vertebral body height,Cobb angle,CT values preand post-operation as well as incidence of complications were used to be observed.All the patients underwent the surgery were successfully followed-up with an average period of 13.54 months(ranging from 6 to 23 months).The patients can ambulate at the second day after the operation.The VAS scores 2 days after the operation and during the last follow-up were significantly decreased compared with that before the operation(P<0.05);the average vertebral height and local Cobb angle had significant recovery(P<0.05);the CT value of the treated vertebra significantly increased compared with that before the operation(P<0.05).MC with good osteogenic activity and degradation properties can effectively improve the mechanical properties and biocompatibility of the PMMA bone cement,thus obtain better clinical results.

关 键 词：mineralized collagen PMMA bone cement OSTEOPOROSIS vertebral compression fractures 

分 类 号：R68[医药卫生—骨科学]