Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy  

作　　者：Chaobo Song Jiapeng Zhang Shuang Li Shengbin Yang Eryi Lu Zhenhao Xi Lian Cen Ling Zhao Weikang Yuan 

机构地区：[1]State Key Laboratory of Chemical Engineering,School of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China [2]Department of Stomatology of Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [3]Shanghai Key Laboratory of Orthopaedic Implant,Department of Orthopaedics Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,No.639,Zhizaoju Road,Shanghai 200011,China

出　　处：《Chinese Journal of Chemical Engineering》2021年第1期426-436,共11页中国化学工程学报（英文版）

基　　金：the National Natural Science Foundation of China (Grant No. 21676083);the Fundamental Research Funds for the Central Universities;111 Project (Grant No. B20031)。

摘　　要：In this study,mesoporous bioactive glass particles(MBGs) are incorporated into poly(lactic-co-glycolic acid)(PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties via a developed supercritical carbon dioxide(scCO_(2)) foaming method Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy.Specifically,scaffolds with porosity from 73% to 85%,pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%.In comparison with neat PLGA scaffolds,composite scaffolds perform improved strength(up to 1.5 folds) and Young's modulus(up to 3 folds).The interconnected macroporous structure is beneficial to the ingrowth of cells.More importantly,composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions.Hopefully,MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological,mechanical and biological features for tissue regeneration.

关 键 词：SCAFFOLD Mesoporous bioactive glass Supercritical carbon dioxide FOAMING Poly(lactic-co-glycolic acid) 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]