手性识别技术研究进展  

Progress on Chiral Recognition Techniques

作　　者：孔泳[1] 赵倩倩 杨嘉佩 尹争志[2] 吴大同 陶永新[1] KONG Yong;ZHAO Qianqian;YANG Jiapei;YIN Zhengzhi;WU Datong;TAO Yongxin(School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China;College of Biological,Chemical Sciences and Engineering,Jiaxing University,Jiaxing 314001,China)

机构地区：[1]常州大学石油化工学院,江苏常州213164 [2]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《常州大学学报（自然科学版）》2021年第2期24-36,共13页Journal of Changzhou University：Natural Science Edition

基　　金：国家自然科学基金资助项目(21775013);浙江省自然科学基金资助项目(LY18B050005)。

摘　　要：手性在自然界中无处不在,手性对映体的理化性质极其相似,但手性对映体特别是手性药物在生理活性等方面却表现出明显的差异,因此,有关手性对映体的手性识别对分析化学和生命科学的研究都具有重要的意义。近年来,虽然有关手性识别技术的研究越来越多,但开发快速灵敏、操作简单的手性识别技术仍是一项重要且具有挑战性的任务。首先总结了已被广泛认可的3种手性识别机理,接着结合本课题组的研究工作对一些常见的手性识别技术进行了归纳和总结,分析了已有手性识别技术的优缺点,为开发新型高效的手性识别技术提供了思路。Chirality is ubiquitous in nature.Enantiomers have highly similar physicochemical properties,however,enantiomers especially chiral drugs behave rather differently in physiological activity.Therefore,it is of significant importance in analytical chemistry and life sciences for the chiral recognition of enantiomers.Although more and more attention has been paid to the development of chiral recognition techniques in recent years,it is still an important and challenging task to develop novel chiral recognition technologies which is rapid,sensitive and simple to operate.In this paper,we first reviewed the widely accepted three mechanisms of chiral recognition,and then summarized some common chiral recognition techniques including those reported by our group and outlined the advantages and limits of these known chiral recognition techniques,which is important for further development of high-efficient chiral recognition techniques.

关 键 词：手性 对映异构体 手性识别机理 手性识别技术 

分 类 号：O657[理学—分析化学]