The Hippo Tumor Suppressor Pathway(YAP/TAZ/TEAD/MST/LATS)and EGFR-RAS-RAF-MEK in cancer metastasis  

作　　者：Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Raposo Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh 

机构地区：[1]Cancer Research Center,Shahid Beheshti University of Medical Sciences,Tehran,Iran [2]Cancer Research Center,Cancer Institute of Iran,Tehran University of Medical Science,Tehran,Iran [3]Department of Immunology,School of Medicine,Tehran University of Medical Sciences,Tehran,Iran [4]Department of Immunology,Medical School,Shahid Beheshti University of Medical Sciences,Tehran,Iran [5]Faculty of Pharmaceutical Sciences State University of Campinas-UNICAMP Campinas,SP,Brazil [6]Cancer Research Center,Shohadae Tajrish Hospital,Department of Radiation Oncology,Shahid Beheshti University of Medical Sciences,Tehran,Iran

出　　处：《Genes & Diseases》2021年第1期48-60,共13页基因与疾病（英文）

摘　　要：Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth.This pathway is activated in response to cell cycle arrest signals(cell polarity,transduction,and DNA damage)and limited by growth factors or mitogens associated with EGF and LPA.The major pathway consists of the central kinase of Ste20 MAPK(Saccharomyces cerevisiae),Hpo(Drosophila melanogaster)or MST kinases(mammalian)that activates the mammalian AGC kinase dmWts or LATS effector(MST and LATS).YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation(TEA domain family,TEAD1-4),stem cells(Oct4 mononuclear factor and SMAD-related TGFb effector),differentiation(RUNX1),and Cell cycle/apoptosis control(p53,p63,and p73 family members).This is due to the diverse roles of YAP and may limit tumor progression and establishment.TEAD also coordinates various signal transduction pathways such as Hippo,WNT,TGFb and EGFR,and effects on lack of regulation of TEAD cancerous genes,such as KRAS,BRAF,LKB1,NF2 and MYC,which play essential roles in tumor progression,metastasis,cancer metabolism,immunity,and drug resistance.However,RAS signaling is a pivotal factor in the inactivation of Hippo,which controls EGFR-RAS-RAF-MEK-ERKmediated interaction of Hippo signaling.Thus,the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer.

关 键 词：Cancer Hippo pathway Metastasis Signaling Tumor suppressor 

分 类 号：R73-37[医药卫生—肿瘤]