配方因素对纤维素胶囊膜性能影响的研究  

Effect of Formula Factors on Properties of Cellulose Capsule Membrane

作　　者：丁慧璞 黄金琴 何淑蕾 罗文钦 刘利萍[1] DING Hui-pu;HUANG Jin-qin;HE Shu-lei;LUO Wen-qin;LIU Li-ping(College of Biology and Environment,Zhejiang Wanli University,Ningbo 315100,China)

机构地区：[1]浙江万里学院生物与环境学院,浙江宁波315100

出　　处：《纤维素科学与技术》2021年第1期9-18,共10页Journal of Cellulose Science and Technology

摘　　要：胶囊膜的质量会直接影响胶囊剂临床使用的安全性和效果。本研究以羟丙甲基纤维素(HPMC)为主要原料,以卡拉胶、KCl和吐温80为主要辅料制备胶囊膜。通过对胶囊膜吸湿性、溶解性、透光性和力学性能的研究,确定出HPMC空心胶囊的最佳配方为:HPMC、卡拉胶、KCl和吐温80在溶剂(纯化水)中的比例分别为18%(m/V)、0.7%(m/V)、0.07%(m/V)和0.018%(m/V)。在此条件下,所得胶囊膜具有较低的吸湿性以及良好的溶解性、光学性能和机械性能。本研究可为HPMC空心胶囊的精确配方和工业化生产提供数据支持。In this study,hydroxypropyl methyl cellulose(HPMC)was used as the main raw material,carrageenan,KCl and Tween 80 were used as the main auxiliary materials to prepare the capsule membrane.Through the study on the hygroscopicity,solubility,light transmittance and mechanical properties of the capsule membrane,the optimal formula of HPMC hollow capsule was determined as follows:The proportion of HPMC,carrageenan,KCl and Tween 80 in the solvent(purified water)was 18%(m/V),0.7%(m/V),0.07%(m/V)and 0.018%(m/V),respectively.Under these conditions,the film has low hygroscopicity,good solubility,optical properties and mechanical properties.This study can provide data support for accurate formulation and industrial production of HPMC hollow capsules.

关 键 词：羟丙基甲基纤维素 胶囊膜 植物空心胶囊 配方 

分 类 号：R944.5[医药卫生—药剂学]