分化型甲状腺癌患者^131I治疗前停服左旋甲状腺激素后血脂、血压与甲状腺功能的相关性分析  

Analysis of the correlations between blood lipid,blood pressure and thyroid function in patients with differentiated thyroid carcinoma after the withdrawal of L-T4 and before ^131I treatment

作　　者：李浩宇 刘超[1] 侯飞 刀钰洋 王昀 邓智勇[1] LI Haoyu;LIU Chao;HOU Fei;DAO Yuyang;WANG Yun;DENG Zhiyong(Department of Nuclear Medicine,Yunnan Cancer Hospital,Yunnan,Kunming 650118,China)

机构地区：[1]云南省肿瘤医院核医学科,云南昆明650118

出　　处：《中国医药科学》2021年第4期1-4,共4页China Medicine And Pharmacy

基　　金：国家自然科学基金(81860312;81960322);云南省科技计划项目(昆医联合专项)[2018FE001(-247)];昆明医科大学研究生创新基金(2020S218)。

摘　　要：目的探讨分化型甲状腺癌(DTC)患者131I治疗前停服左旋甲状腺激素(L-T4)后血脂、血压与甲状腺功能的相关性。方法回顾性分析云南省肿瘤医院116例DTC患者停服L-T4前后的甲状腺功能与血脂、血压的相关性。结果停药后甲减组三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(CHOL)、载脂蛋白B(ApoB)及舒张压(DBP)均高于停药前正常组,甲减组载脂蛋白A/载脂蛋白B(ApoA/ApoB)低于正常组(P<0.05)。甲减组高血压患病率(42.2%)高于正常组(29.3%)(P=0.040)。甲减组与正常组促甲状腺素(TSH)水平与各血脂及血压指标间均无明显相关性(P>0.05)。停药后甲减组患者分为TSH<50μIU/ml组和TSH≥50μIU/ml组,两组的血脂、血压水平及高血压患病率比较,差异均无统计学意义(P>0.05)。结论DTC患者131I治疗前停服L-T4后发生甲状腺功能减退时血脂及血压均发生异常,甲状腺功能减退达一定程度后血脂及血压变化不大。Objective To investigate the correlations between blood lipid(BL),blood pressure(BP)and thyroid function in the patients with differentiated thyroid carcinoma(DTC)after the withdrawal of L-T4 and before 131I treatment.Methods The correlations between BL,BP and thyroid function before and after the withdrawal of L-T4 from 116 patients with DTC in Yunnan Cancer Hospital were analyzed retrospectively.Results After drug withdrawal,the levels of triglyceride(TG),low density lipoprotein cholesterol(LDL-C),total cholesterol(CHOL),apolipoprotein B(ApoB)and diastolic blood pressure(DBP)in the hypothyroidism group were all higher than those in the normal group before drug withdrawal,and the levels of the apolipoprotein A/apolipoprotein B(ApoA/ApoB)in the hypothyroidism group were lower than those in the normal group(P<0.05).The prevalence of hypertension in the hypothyroidism group(42.2%)was higher than that in the normal group(29.3%)(P=0.040).There were no significant correlations between the TSH level and the indices of BL and BP in both the hypothyroidism group and the normal group(P>0.05).After drug withdrawal,the patients with hypothyroidism were divided into the TSH<50μIU/ml group and the TSH≥50μIU/ml group.The results showed that there were no statistically significant differences in the levels of BL and BP and the prevalence of hypertension between the two groups(P>0.05).Conclusion After the withdrawal of L-T4 and before 131I treatment,DTC patients exhibit abnormal BL and BP when hypothyroidism occurs.No significant change in BL and BP after hypothyroidism reached a certain degree.

关 键 词：分化型甲状腺癌 甲状腺功能减退 血脂 血压 

分 类 号：R736.1[医药卫生—肿瘤]