细胞焦亡与炎症性肠病  

Pyropotosis and inflammatory bowel disease

作　　者：祁雅婷 张峰睿[1] 缪应雷[1] Qi Yating;Zhang Fengrui;Miao Yinglei(Department of Gastroenterology,The First Affiliated Hospital,Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院消化内科,650032

出　　处：《中华炎性肠病杂志（中英文）》2021年第1期92-95,共4页Chinese Journal of Inflammatory Bowel Diseases

摘　　要：细胞焦亡是一种主要依赖半胱氨酸天冬氨酸蛋白酶-1的促炎程序性细胞死亡,特征是快速的膜破裂和促炎细胞内容物的释放。炎症性肠病(IBD)是一种病因不明的慢性消化道炎症,可能与肠道的上皮屏障功能、共生微生物群、饮食和免疫系统的改变等有关。目前很多研究证明细胞凋亡、细胞自噬在IBD中的作用,而区别于前两者但有与之具有千丝万缕联系的细胞焦亡也逐渐被发现,并证实可能存在于IBD的病程之中。本文将针对细胞焦亡与IBD的联系进行综述。Pyropotosis is a pro-inflammatory programmed pattern of cell death which mainly depends on caspase-1,which is characterized by the rapid membrane rupture and the release of pro-inflammatory intracellular contents.Inflammatory bowel disease is a chronic intestinal inflammation caused by unknown etiology,which may be associated with the changes of intestinal epithelial barrier function,symbiotic microorganisms,diet and the immune system.At present,many studies have demonstrated the effect of apoptosis and autophagy on IBD,and pyropotosis has been confirmed to exist in IBD probablely,which is different from the apoptosis and autophagy but has close relation with the two.This article reviews the association between pyropotosis and IBD.

关 键 词：炎症性肠病 细胞焦亡 半胱氨酸天冬氨酸蛋白酶-1 Gasdermin D 

分 类 号：R574[医药卫生—消化系统]