轮班工作与卵巢癌关系的研究进展  

Research Progress on Relation Between Shift Work and Ovarian Cancer

作　　者：高畅 张爽 闻赵燕 宫婷婷[3] 赵玉虹[1,2] 吴琪俊[1,2] GAO Chang;ZHANG Shuang;WEN Zhaoyan;GONG Tingting;ZHAO Yuhong;WU Qijun(Department of Clinical Epidemiology,Shengjing Hospital,China Medical University,Shenyang 110004,China;Department of Clinical Research Center,Shengjing Hospital,China Medical University,Shenyang 110004,China;Department of Obstetrics and Gynecology,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院临床流行病学教研室,沈阳110004 [2]中国医科大学附属盛京医院临床研究中心,沈阳110004 [3]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《肿瘤防治研究》2021年第3期293-298,共6页Cancer Research on Prevention and Treatment

基　　金：国家重点研发计划(2017YFC0907404);国家自然科学基金(81602918);中国博士后科学基金面上项目(2018M641752);辽宁省“兴辽英才计划”(XLYC1907102);沈阳市中青年科技创新人才支持计划(RC190484);国家自然科学基金(82073647)。

摘　　要：卵巢癌发病率居女性恶性肿瘤第三位,死亡率居首位,且预后较差,对女性生命健康造成严重威胁,其发病及预后与遗传、内分泌失调以及不良生活方式等因素有关。近年来,有学者开展了生活方式,特别是轮班工作与卵巢癌发生及发展关系的研究。轮班工作会导致昼夜节律紊乱,影响体内的激素平衡,可能是卵巢癌的危险因素。本综述归纳了轮班工作与卵巢癌关系的4项队列研究和2项病例对照研究,但研究结论尚不一致,其与卵巢癌的关系仍需进一步探索。The incidence rate of ovarian cancer ranks the third among female malignant tumors,the mortality rate ranks the first and the prognosis is poor.Ovarian cancer poses a serious threat to the health of women's lives.The incidence of ovarian cancer is related to heredity,endocrine disorders and adverse lifestyle factors.In recent years,some scholars have carried out the impact of lifestyle,especially shift work,on the occurrence and development of ovarian cancer.Shift work can lead to circadian disruption,which affects hormonal balance in the body and may be a risk factor for ovarian cancer.This review summarizes four cohort studies and two case-control studies on the relation between shift work and ovarian cancer.The conclusion of the studies is inconsistent,suggesting that further researches are needed.

关 键 词：卵巢癌 轮班工作 机制 

分 类 号：R737.31[医药卫生—肿瘤]