Protein Quality Control in Plant Organelles:Current Progress and Future Perspectives  

作　　者：Jing-Liang Sun Jin-Yu Li Mei-Jing Wang Ze-Ting Song Jian-Xiang Liu 

机构地区：[1]State Key Laboratory of Plant Physiology and Biochemistry,College of Life Sciences,Zhejiang University,Hangzhou 310027,China

出　　处：《Molecular Plant》2021年第1期95-114,共20页分子植物（英文版）

基　　金：Projects associated with protein homeostasis in the Liu Lab are financially supported by grants from the National Natural Science Foundation of China(31625004,31872653,and 31800210);the Zhejiang Provincial Talent Program(2019R52005);the 111 Project(B14027).

摘　　要：The endoplasmic reticulum,chloroplasts,and mitochondria are major plant organelles for protein synthesis,photosynthesis,metabolism,and energy production.Protein homeostasis in these organelles,maintained by a balance between protein synthesis and degradation,is essential for cell functions during plant growth,development,and stress resistance.Nucleus-encoded chloroplast-and mitochondrion-targeted proteins and ER-resident proteins are imported from the cytosol and undergo modification and maturation within their respective organelles.Protein folding is an error-prone process that is influenced by both developmental signals and environmental cues;a number of mechanisms have evolved to ensure efficient import and proper folding and maturation of proteins in plant organelles.Misfolded or damaged proteins with nonnative conformations are subject to degradation via complementary or competing pathways:intraorganelle proteases,the organelle-associated ubiquitin-proteasome system,and the selective autophagy of partial or entire organelles.When proteins in nonnative conformations accumulate,the organellespecific unfolded protein response operates to restore protein homeostasis by reducing protein folding demand,increasing protein folding capacity,and enhancing components involved in proteasome-associated protein degradation and autophagy.This review summarizes recent progress on the understanding of protein quality control in the ER,chloroplasts,and mitochondria in plants,with a focus on common mechanisms shared by these organelles during protein homeostasis.

关 键 词：AUTOPHAGY chloroplast-associated protein degradation ER-associated protein degradation mitochondria-associated protein degradation protein quality control unfolded protein response 

分 类 号：Q946.1[生物学—植物学]