A型肉毒毒素治疗慢性偏头痛的临床研究  

A Clinical Study of Botulinum Toxin Type A in the Treatment of Chronic Migraine

作　　者：陈成芳[1] 施俊峰[1] 宗惠花[1] 汤武装 赵彦平[1] CHEN Cheng-fang;SHI Jun-feng;ZONG Hui-hua;TANG Wu-zhuang;ZHAO Yan-ping(Department of Neurology,Yixing People's Hospital,Yixing,Jiangsu Province,214200 China)

机构地区：[1]宜兴市人民医院神经内科,江苏宜兴214200

出　　处：《系统医学》2021年第1期68-70,共3页Systems Medicine

基　　金：A型肉毒毒素的临床应用(JLY20180065)。

摘　　要：目的探析A型肉毒毒素治疗慢性偏头痛患者的临床疗效。方法将50例2019年1月—2020年2月在该院治疗的慢性偏头痛患者选为观察对象,按照随机原则分成对照组与研究组。对照组25例患者予以醋酸泼尼松龙与2%利多卡因治疗,研究组25例患者予以A型肉毒毒素治疗,对两组患者临床疗效、疼痛程度、疼痛发作时间予以统计比较。结果针对临床总有效率而言,研究组患者(96.00%)明显高于对照组患者(68.00%),组间比较差异有统计学意义(χ^(2)=5.357,P<0.05)。在疼痛程度上,研究组治疗1、3个月后疼痛评分均较治疗前下降,且研究组低于对照组,差异有统计学意义(t=4.250、8.610,P<0.05);同时,对照组治疗1个月后疼痛评分明显低于治疗前,差异有统计学意义(P<0.05)。在疼痛发作时间上,两组治疗1个月后均较治疗前缩短,且研究组明显短于对照组;研究组治疗3个月后较治疗前缩短,同时明显短于对照组,差异有统计学意义(t=5.460、7.240,P<0.05)。结论A型肉毒毒素治疗慢性偏头痛患者的效果十分确切,不仅可以减轻患者疼痛程度,还可以缩短患者疼痛发作时间,值得临床推广应用。Objective To explore the clinical efficacy of botulinum toxin type A in the treatment of chronic migraine patients.Methods Fifty patients with chronic migraine who were treated in the hospital from January 2019 to February 2020 were selected as observation objects,and divided into control group and study group according to the principle of randomization.25 patients in the control group were treated with prednisolone acetate and 2%lidocaine,and 25 patients in the study group were treated with botulinum toxin type A.The clinical efficacy,pain degree and pain onset time of the two groups were statistically compared.Results In terms of the total clinical effective rate,patients in the study group(96.00%)were significantly higher than those in the control group(68.00%),and the difference between the groups was statistically significant(χ^(2)=5.357,P<0.05).In terms of pain,the pain scores of the study group were lower than before treatment after 1 month and 3 months,and the study group was lower than the control group,the difference was statistically significant(t=4.250,8.610,P<0.05);at the same time,the control group's pain score after 1 month was significantly lower than before treatment,the difference was statistically significant(P<0.05).In terms of pain onset time,both groups were shorter than before treatment after 1 month of treatment,and the study group was significantly shorter than the control group;the study group was shorter than before treatment after 3 months of treatment,and at the same time was significantly shorter than the control group,the difference was statistically significnat(t=5.460,7.240,P<0.05).Conclusion Botulinum toxin type A is very effective in the treatment of patients with chronic migraine.It can not only reduce the pain of patients,but also shorten the time of pain onset,and it is worthy of clinical application.

关 键 词：慢性偏头痛 A型肉毒毒素 临床疗效 疼痛程度 疼痛发作时间 

分 类 号：R747[医药卫生—神经病学与精神病学]