呼吸科住院患者抗生素药物相关腹泻发生现状及影响因素分析  

Antibiotic associated diarrhea and its influencing factors in patients with respiratory diseases

作　　者：赵东芳[1] 陈晨[1] 苏春燕[2] 张会芝[1] 刘然 侯月梅 孙雪 ZHAO Dong-fang;CHEN Chen;SU Chun-yan;ZHANG Hui-zhi;LIU Ran;HOU Yue-mei;SUN Xue(Department of Respiratory and Critical Care Medicine,Peking University Third Hospital,Beijing 100191,China;不详)

机构地区：[1]北京大学第三医院呼吸与危重症医学科 [2]北京大学第三医院肾内科,北京100191

出　　处：《中国微生态学杂志》2021年第2期205-208,213,共5页Chinese Journal of Microecology

摘　　要：目的了解呼吸科住院患者抗生素药物相关腹泻发生现状并探讨相关影响因素。方法选取2019年1月-2019年9月我院呼吸科病房收治使用抗生素治疗的患者为研究对象,采用前瞻性队列研究,收集患者基本资料、抗生素使用情况及相关因素,以探讨抗生素药物相关腹泻的影响因素。结果本研究共纳入291例患者,抗生素药物相关腹泻发生率为11.3%。COX回归显示,入院时便潜血(OR=4.730,P<0.001)、BMI(OR=0.918,P=0.027)、入院时血红蛋白水平(OR=0.974,P=0.007)、院前抗生素使用(OR=3.246,P=0.011)、单日使用抗生素最大种类数(OR=2.665,P=0.001)为抗生素药物相关腹泻的影响因素,便潜血阳性患者较阴性患者抗生素药物相关腹泻发生率高,入院时BMI、血红蛋白水平低,住院前已开始使用抗生素,单日抗生素使用种类多的患者抗生素药物相关腹泻发生率高。结论抗生素药物相关腹泻为呼吸科住院患者中常见的并发症,临床上对于便潜血阳性患者、BMI和/或血红蛋白水平较低的患者、住院前已开始使用抗生素的患者、感染较重需联合使用抗生素的患者,应在行抗生素治疗方案前做好抗生素药物相关腹泻的预防工作。Objective To investigate antibiotic associated diarrhea and its influencing factors in patients with respiratory diseases. Methods Patients with respiratory diseases admitted and treated with antibiotics in our hospital during January, 2019 and September, 2019 were recruited. Using prospective cohort study, patient information on general data, use of antibiotics, and the related factors were analyzed to explore the influencing factors. Results Among the 291 patients included, the incidence of antibiotic associated diarrhea was 11.3%. Cox regression model revealed that the factors related to a higher incidence of antibiotic associated diarrhea were positive fecal occult blood test, decreased BMI, decreased hemoglobin, use of antibiotics before hospitalization, and combined use of antibiotics per day. Conclusion Antibiotic associated diarrhea is a common complication in respiratory inpatients. Prevention of antibiotic associated diarrhea should be taken for patients with positive fecal occult blood test, decreased BMI and/or hemoglobin, use of antibiotics before hospitalization, and combined use of antibiotics.

关 键 词：呼吸道疾病 抗生素药物相关腹泻 影响因素 

分 类 号：R574.4[医药卫生—消化系统]