人体肠道微生态与肝脏免疫关系研究进展  

Advances in research on relationship between human intestinal microecology and liver immunity

作　　者：吴永娜 张磊[4,5] 陈拓[1,3] 李汛 刘光琇 WU Yong-na;ZHANG Lei;CHEN Tuo;LI Xun;LIU Guang-xiu(Northwest Institute of Eco Environment and Resources,Chinese Academy of Sciences,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]中国科学院西北生态环境资源研究院,甘肃兰州730000 [2]中国科学院大学,北京100049 [3]中国科学院西北生态环境资源研究院沙漠与沙漠化重点实验室,甘肃兰州730000 [4]兰州大学第一医院,甘肃兰州730000 [5]甘肃省生物治疗与再生医学重点实验室,甘肃兰州730000

出　　处：《中国微生态学杂志》2021年第2期227-230,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金(31960236,31770536);兰州市人才创新创业项目(2019-RC-34)。

摘　　要：人体微生态学是研究微生物与其宿主相互关系的科学,其中肠道微生态对于人体有最直接的作用。肠道微生态是一个被遗忘的"人体新陈代谢器官",具有维持能量稳态等重要的生理作用。肝脏是人类的重要器官,肝脏中四分之三的血液来自于肠道回流血,其中含有肠道中的细菌产物、环境毒素和食物抗原等。因此肝脏与肠道有最直接的关系。人体肠道微生态中的大量微生物不仅参与调控肠道内的免疫应答,还参与调控肝脏等器官的免疫反应,因此肠道微生态与肝脏免疫密不可分。本文就肠道微生态与肝脏免疫的相关性研究作一综述,以期为人体微生态与肝脏免疫的相关研究提供科学依据。Human microecology is the science that studies the relationship between microorganisms and their hosts.Gastrointestinal microecology has the most direct effect on the human body. Intestinal microecology is a forgotten human metabolic organ that has important physiological functions such as maintaining energy homeostasis.Liver is an important organ of human beings.3/4 of the blood in the liver comes from the blood of intestine, which contains bacterial products in the intestines, environmental toxins and food antigens.Therefore, liver has the most direct relationship with intestines.A large number of microorganisms in the human intestinal micro-ecology environment not only participate in the regulation of immune response in the intestine, but also participate in the regulation of immune responses in the body organs such as liver. Therefore, intestinal micro-ecology is inseparable from liver immunity. This paper reviews the correlation between intestinal microecology and liver immunity, in order to provide a scientific basis for the study on human microecology and liver immunity.

关 键 词：肠道 微生态 肝脏 免疫 

分 类 号：Q939.93[生物学—微生物学] R735[医药卫生—肿瘤]