胸水IFN-γ、ADA、CEA、CA125检测对良恶性胸腔积液鉴别诊断的价值分析  

The value analysis of IFN-γ, ADA, CEA, CA125 in pleural effusion for the differential diagnosis of benign and malignant pleural effusion

作　　者：李美岩 LI Mei-yan(Shenyang Tenth People's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第十人民医院,110000

出　　处：《中国实用医药》2021年第7期22-24,共3页China Practical Medicine

摘　　要：目的分析胸水干扰素-γ(IFN-γ)、腺苷脱氨酶(ADA)、癌胚抗原(CEA)、糖类抗原125(CA125)检测对良恶性胸腔积液鉴别诊断的价值。方法选取96例胸腔积液患者,根据病理诊断结果分为良性组(44例)和恶性组(52例)。两组均行胸水IFN-γ、ADA、CEA、CA125检测。比较两组患者胸水IFN-γ、ADA、CEA、CA125水平,并比较单一检测与联合检测(胸水IFN-γ、ADA、CEA、CA125联合检测)的诊断效能。结果良性组胸水IFN-γ(498.34±210.01)ng/L、ADA(52.66±11.38)ng/ml高于恶性组的(80.27±38.52)ng/L、(18.21±6.54)ng/ml, CEA(10.42±4.27)ng/ml、CA125(68.27±16.57)ng/ml均低于恶性组的(87.64±32.14)、(188.34±55.32)ng/ml,差异有统计学意义(P<0.05)。联合检测诊断的敏感度、特异度及准确度均高于IFN-γ、ADA、CEA、CA125单一检测,差异有统计学意义(P<0.05)。结论临床上对良恶性胸腔积液进行鉴别诊断时,联合检测胸水IFN-γ、ADA、CEA、CA125等多项指标,能够为临床治疗提供准确的指导依据。Objective To analyze the value of interferon-γ(IFN-γ), adenosine deaminase(ADA), carcinoembryonic antigen(CEA), carbohydrate antigen 125(CA125) in pleural effusion for the differential diagnosis of benign and malignant pleural effusion. Methods A total of 96 patients with pleural effusion were divided into benign group(44 cases) and malignant group(52 cases) according to pathological diagnosis. Both groups were tested for IFN-γ, ADA, CEA, CA125. The levels of IFN-γ, ADA, CEA, and CA125 in pleural fluid of the two groups were compared, and the diagnostic efficacy of single test and combined test(combined test of IFN-γ, ADA, CEA, CA125 in pleural fluid) was compared. Results The IFN-γ(498.34±210.01) ng/L and ADA(52.66±11.38) ng/ml of benign group were higher than(80.27±38.52) ng/L and(18.21±6.54) ng/ml of malignant group, and CEA(10.42±4.27) ng/ml and CA125(68.27±16.57) ng/ml were all lower than(87.64± 32.14) and(188.34±55.32) ng/ml of malignant group, and the difference was statistically significant(P<0.05). The sensitivity, specificity and accuracy of combined test were higher than that of IFN-γ, ADA, CEA, CA125 single test, and the difference was statistically significant(P<0.05). Conclusion Combined test of IFN-γ, ADA, CEA and CA125 can provide accurate guidance for clinical differential diagnosis of benign and malignant pleural effusion.

关 键 词：胸水干扰素-γ 腺苷脱氨酶 癌胚抗原 糖类抗原125 良恶性胸腔积液 鉴别诊断 

分 类 号：R730.43[医药卫生—肿瘤]