YAP/TAZ的调控机制研究进展  

Research progress of YAP/TAZ regulation mechanism

作　　者：陈林云 欧阳家和 段琼 朱凌燕[1] CHEN Lin-Yun;OUYANG Jia-He;DUAN Qiong;ZHU Ling-Yan(Department of Endocrinology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;The First Clinical Medical College of Nanchang University,Nanchang 330006,China;Department of Cardiology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院内分泌科,南昌330006 [2]南昌大学第一临床医学院,南昌330006 [3]南昌大学第一附属医院心血管科,南昌330006

出　　处：《生命科学》2020年第12期1381-1390,共10页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81860153);南昌大学研究生创新专项资助基金项目(CX2019121)。

摘　　要：YAP/TAZ是Hippo通路的关键效应因子,在介导Hippo通路调节器官大小及组织恶变中起着重要作用。近年来的研究发现,除了经典Hippo通路,机械信号如Rho激酶和细胞核内因素,可溶性因子如GPCR、Wnt和转化生长因子-β(TGF-β)信号通路,以及能量代谢等对YAP/TAZ也起到了多方面的调控作用。越来越多的研究表明,YAP/TAZ在肿瘤、心血管疾病和肥胖等多种疾病中发挥着重要作用。因此,深入探究YAP/TAZ的调控机制显得尤为重要。现对哺乳动物系统YAP/TAZ的调控机制研究进行综述,希望为多种疾病治疗提供新的思路。Hippo pathway is a very conservative pathway in evolution and function.YAP/TAZ is a key effector of the Hippo pathway,which plays an important role in regulating organ size and tissue malignancy.Recent studies have found that in addition to the classic Hippo pathway,mechanical signaling such as Rho kinase and nuclear factors,soluable factors such as GPCR,Wnt and transforming growth factor beta(TGF-β)signaling pathway,energy metabolism,etc.also play a multi-faceted regulatory role on YAP/TAZ.As an increasing number of reports uncover the fact that YAP/TAZ plays an important role in the occurrence and development of tumors,cardiovascular diseases,obesity and other diseases,it is particularly important to explore the regulatory mechanism of YAP/TAZ in depth.This article reviews the regulatory mechanism of YAP/TAZ in the mammalian system to provide new ideas for the treatment of various diseases.

关 键 词：YAP/TAZ Hippo通路 RHO激酶 细胞核内因素 WNT信号通路 TGF-Β信号通路 能量代谢 调控机制 

分 类 号：R363[医药卫生—病理学]