术前新辅助化学治疗联合宫颈癌根治术治疗宫颈癌的疗效  

Efficacy of preoperative neoadjuvant chemotherapy combined with radical hysterectomy for cervical cancer

作　　者：赵骞 李双月[1] 赵铁男 ZHAO Qian;LI Shuang-yue;ZHAO Tie-nan(Shenyang Maternity and Infant Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市妇婴医院,110000

出　　处：《中国实用医药》2021年第9期7-9,共3页China Practical Medicine

摘　　要：目的分析在宫颈癌患者中采取术前新辅助化学治疗(化疗)联合宫颈癌根治术的效果。方法80例宫颈癌患者,通过随机数字表法分为观察组与对照组,各40例。对照组采取宫颈癌根治术治疗,观察组采取术前新辅助化疗联合宫颈癌根治术治疗。比较两组手术及术后恢复情况、术后免疫功能指标、术后病理情况。结果观察组手术时间(170.58±15.75)min、术后住院时间(15.32±5.87)d短于对照组的(191.45±18.47)min、(18.47±6.86)d,差异有统计学意义(P<0.05)。观察组术中出血量(370.42±30.56)ml少于对照组的(480.56±36.96)ml,差异有统计学意义(P<0.05)。术后,观察组CD3+、CD4+、CD8+、CD4+/CD8+优于对照组,差异有统计学意义(P<0.05)。观察组术后盆腔淋巴结转移率7.50%低于对照组的32.50%,差异有统计学意义(P<0.05)。观察组深肌层浸润率22.50%低于对照组的50.00%,差异有统计学意义(P<0.05)。观察组脉管癌栓率5.00%低于对照组的27.50%,差异有统计学意义(P<0.05)。观察组阴道切缘转移率7.50%低于对照组的25.00%,差异有统计学意义(P<0.05)。结论术前新辅助化疗联合宫颈癌根治术应用于宫颈癌患者中,可有效提高患者免疫功能,缩短手术时间,加快术后恢复,提升手术效果,值得广泛应用。Objective To analyze the effect of preoperative neoadjuvant chemotherapy combined with radical hysterectomy for cervical cancer.Methods A total of 80 patients with cervical cancer were divided into observation group and control group according to random numerical table,with 40 cases in each group.The control group was treated with radical hysterectomy,and the observation group was treated with preoperative neoadjuvant chemotherapy combined with radical hysterectomy.The surgery and postoperative recovery,postoperative immune function and postoperative pathology were compared between the two groups.Results The operation time(170.58±15.75)min and postoperative hospitalization time(15.32±5.87)d of the observation group were shorter than(191.45±18.47)min and(18.47±6.86)d of the control group,and the difference was statistically significant(P<0.05).The intraoperative blood loss(370.42±30.56)ml of the observation group was less than(480.56±36.96)ml of the control group,and the difference was statistically significant(P<0.05).After operation,the levels of CD3~+,CD4~+,CD8~+and CD4~+/CD8~+of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).The postoperative pelvic lymph node metastasis rate 7.50%of the observation group was lower than 32.50%of the control group,and the difference was statistically significant(P<0.05).The deep muscle layer infiltration rate 22.50%of the observation group was lower than 50.00%of the control group,and the difference was statistically significant(P<0.05).The vascular cancer thrombus rate 5.00%of the observation group was lower than 27.50%of the control group,and the difference was statistically significant(P<0.05).The vaginal margin metastasis rate 7.50%of the observation group was lower than 25.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion The application of preoperative neoadjuvant chemotherapy and radical hysterectomy in patients with cervical cancer can effectively

关 键 词：宫颈癌 新辅助化学治疗 宫颈癌根治术 免疫功能 

分 类 号：R737.33[医药卫生—肿瘤]