神经发育疾病相关Tenascin C表达的分子调控通路  

Molecular Regulatory Pathways of Tenascin C Expression in Neurodevelopmental Diseases

作　　者：苏琦 姜鸣 杨清湖[1,2,3,4] 杨亮 何建秧[1] 刘霞 白占涛 SU QI;JIANG MING;YANG Qing-hu;YANG LIANG;HE Jian-yang;LIU XIA;BAI Zhan-tao(School of Life Sciences,Yan′an University;Research Center for Resources Peptide Drug;Yan′an Engineering&Technological Research Center for Regional Biological Resources;Shaanxi Engineering&Technological Research Center for Conservation&Utilization of Regional Biological Resources,Yan′an 716000,China)

机构地区：[1]延安大学生命科学学院 [2]多肽资源药物研究中心 [3]延安市特色资源生物工程技术研究中心 [4]陕西省区域生物资源保育与利用工程技术研究中心,陕西延安716000

出　　处：《延安大学学报（自然科学版）》2021年第1期17-22,共6页Journal of Yan'an University：Natural Science Edition

基　　金：国家自然科学基金项目(31860270,31760275,81470051);陕西省科技厅项目(2018ZDCXL-SF-01-04,2018ZDXM-NY-038,2017KCT-35);延安市科技局项目(2015CXTD-06);延安大学校科研项目(YDQ2018-20,YDBK2017-23,YDBK2019-14,YDBK2019-41,CXY201903);延安大学大学生创新创业训练计划(D2020088)。

摘　　要：胞外基质Tenascin C(TNC)是肌腱蛋白Tenascins家族的主要成员之一。TNC转录调控元件多样性,呈现为独特的细胞发育时空表达,进而参与不同神经疾病的发生。本文基于TNC基因表达元件组构与TNC蛋白合成、转运、分泌视角,探析神经发育疾病相关Tenascin C表达的分子调控通路,以期丰富神经发育相关疾病发生机制的新理解,提出以调节型胞外基质蛋白网络重构为靶向的诊疗新策略。Tenascin C(TNC)is one of the main members of extracellular matrix Tenascin family.TNC transcriptional regulatory elements are diverse,showing a unique spatio-temporal expression of cell development,and then participate in the occurrence of different neurological diseases.Based on the perspective of TNC gene expression element fabricand TNC protein synthesis,transport and secretion,this paper explores the molecular regulatory pathnway of Tenascin C expression related to neurodeveopmental diseases,and proposes a new diagnosis and treatment strategy targeting the remodeling of regulatory extracellular matrix protein network,in order to enrich the new understanding of the pathogenesis of neurodevelopmental diseases.

关 键 词：肌腱蛋白C 胞外基质 转录调控元件 神经疾病 神经发育 

分 类 号：R741[医药卫生—神经病学与精神病学]