参麻益智方联合银杏叶片治疗血管性痴呆气虚血瘀阳亢证效果分析  

Effect analysis of Shenma Yizhi prescription combined with ginkgo biloba leaf in the treatment of vascular dementia syndrome of Qi deficiency,blood stasis and Yang hyperactivity

作　　者：李静 Li Jing

机构地区：[1]巩义市人民医院体检中心,451200

出　　处：《中国疗养医学》2021年第4期426-429,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的探究参麻益智方联合银杏叶片治疗血管性痴呆(VD)气虚血瘀阳亢证效果。方法选择2018年9月至2019年8月在某院接受治疗的134例气虚血瘀阳亢证VD患者,随机数字表分为两组各67例。对照组采用常规西医综合治疗,观察组在此基础上联合参麻益智方以及银杏叶片治疗。对比两组治疗效果、认知功能、痴呆程度、生活能力及实验室指标变化。结果观察组治疗效果显著优于对照组(P<0.05)。治疗后,观察组蒙特利尔认知量表(MoCA)、长谷川痴呆量表(HDS)、日常生活能力量表(ADL)评分优于对照组(P<0.001)。观察组神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)、同型半胱氨酸(Hcy)、乙酰胆碱(Ach)表达优于对照组(P<0.05)。结论对VD患者采用参麻益智方联合银杏叶片治疗可提高治疗效果,减轻脑损伤、神经毒性,保护神经元,以改善认知功能,降低痴呆病情程度,提高生活质量。Objective To explore the effect of Shenma Yizhi prescription combined with ginkgo biloba leaf in the treatment of vascular dementia(VD)syndrome of Qi deficiency,blood stasis and Yang hyperactivity.Methods A total of 134 patients with VD of Qi deficiency,blood stasis and Yang hyperactivity treated in a hospital from September 2018 to August 2019 were divided into two groups(with 67 cases in each group)by Random Number Table method.The control group was treated with conventional Western medicine,and the observation group was treated with Shenma Yizhi prescription combined with ginkgo biloba leaf on the basis of conventional Western medicine.The therapeutic effect,cognitive function,dementia degree,living ability and laboratory indexes were compared between the two groups.Results The therapeutic effect of the observation group was significantly better than that of the control group(P<0.05).After treatment,scores of Montreal Cognitive Assessment(MoCA),Hastgawa Dementia Scale(HDS)and Activity of Daily Living(ADL)scale in the observation group were better than those in the control group(P<0.001).The expressions of neuron-specific enolase(NSE),brain-derived neurotrophic factor(BDNF),Homocysteine(Hcy)and Acetylcholine(Ach)in the observation group were superior to those in the control group(P<0.05).Conclusion The treatment of patients with VD by Shenma Yizhi prescription combined with ginkgo biloba leaves can improve the therapeutic effect,reduce brain damage and neurotoxicity,protect neurons,mprove cognitive function,reduce the degree of dementia and improve the quality of life.

关 键 词：参麻益智方 银杏叶片 血管性痴呆 治疗效果 

分 类 号：R749.13[医药卫生—神经病学与精神病学]