25-(OH)-D_(3)水平对结肠癌术后并发症的影响  

Effects of 25 hydroxyvitamin D_(3)level on postoperative complications of colon cancer

作　　者：刘洋[1] 刘俊茹[2] 孟祥彩 王益民[1] LIU Yang;LIU Junru;MENG Xiangcai(Department of General Surgery,The First Hospital of Qinhuangdao City,Hebei,Qinhuangdao 066000,China;不详)

机构地区：[1]河北省秦皇岛市第一医院普通外科,066000 [2]河北省秦皇岛市第一医院内分泌科,066000

出　　处：《河北医药》2021年第5期719-722,共4页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题计划(编号:20181186)。

摘　　要：目的探讨25羟维生素D[25-(OH)-D_(3)]水平对结肠癌术后并发症的影响。方法普外科行肠镜检查且病理证实为结肠癌患者100例,按25-(OH)-D_(3)中位数水平42.2 nmol/L分组,25-(OH)-D_(3)≥42.2 nmol/L组51例,25-(OH)-D_(3)<42.2 nmol/L组49例,测量体重指数(BMI),术前空腹抽血测定25-(OH)-D_(3)、空腹血糖、肝功能、肾功能、血红蛋白水平。观察患者术后肺炎、切口感染、尿路感染、腹腔感染、吻合口瘘、深静脉血栓、肠梗阻、出血和转移的发生情况。结果25-(OH)-D_(3)<42.2 nmol/L组较25-(OH)-D_(3)≥42.2 nmol/L组的BMI明显增高(P<0.05)且术后出现肺炎、切口感染、肝转移的比例也明显增高,差异有统计学意义(P<0.05)。Logistic回归分析显示:25-(OH)-D_(3)<42.2 nmol/L患者发生术后肺炎和肝转移的比例分别是25-(OH)-D_(3)≥42.2 nmol/L患者的2.241和4.178倍,差异均有统计学意义(P<0.05)。结论结肠癌患者合并低维生素D水平时术后发生肺炎及肝转移的比例增高。Objective To investigate the effects of 25 hydroxyvitamin D_(3)[25-(OH)-D_(3)]levels on postoperative complications of colon cancer.Methods A total of 100 patients who underwent colonoscopy and were pathologically confirmed as colon cancer were enrolled in the study.According to the median level of 25-(OH)-D_(3)(42.2nmol/L),these patients were divided into 25-(OH)-D_(3)≥42.2nmol/L group(n=51)and 25-(OH)-D_(3)<42.2nmol/L group(n=49).The levels of BMI,25 hydroxyvitamin D_(3),fasting blood glucose,hemoglobin,and liver function,kidney function were detected,moreover,the incidence rates of postoperative pneumonia,incision infection,urinary tract infection,abdominal infection,anastomotic fistula,deep vein thrombosis,intestinal obstruction,bleeding and metastasis were observed and compared between the two groups.Results The BMI levels and the incidence rates of postoperative pneumonia,incision infection and liver metastasis in 25OHD_(3)<42.2nmol/L group were significantly higher than those in 25-(OH)-D_(3)≥42.2nmol/L group(P<0.05).Logistic regression analysis showed that the incidence rates of postoperative pneumonia and liver metastasis in patients with 25OHD_(3)<42.2nmol/L were 2.241 times and 4.178 times as high as those in patients with 25-(OH)-D_(3)≥42.2nmol/L(P<0.05).Conclusion The incidence rates of postoperative pneumonia and liver metastasis are increased in the patients with colon cancer complicated with low vitamin D levels.

关 键 词：25羟维生素D3 结肠癌 术后并发症 

分 类 号：R735.35[医药卫生—肿瘤]