放疗联合阿帕替尼与同步放化疗治疗晚期食管癌的效果比较  

Therapeutic effects of radiotherapy combined with apatinib as well as simultaneous radiotherapy and chemotherapy on advanced esophageal carcinoma

作　　者：尹小祥[1] 叶宏勋[1] 马慧[1] YIN Xiaoxiang;YE Hongxun;MA Hui(Department of Radiotherapy,Taixing People’s Hospital, Jiangsu, Taixing 225400,China)

机构地区：[1]江苏省泰兴市人民医院肿瘤放疗科,225400

出　　处：《河北医药》2021年第5期723-725,729,共4页Hebei Medical Journal

基　　金：南京医科大学康达学院院级课题项目(编号:KD2016KYJJYB005)。

摘　　要：目的探讨放疗联合阿帕替尼与同步放化疗治疗晚期食管癌临床效果。方法选取2016年1月至2018年1月收治的晚期食管癌患者80例,采用随机数字表法分为A组(40例)和B组(40例),A组采用同步放化疗治疗,B组采用放疗联合阿帕替尼治疗。比较2组近期疗效、血清肿瘤标志物水平、生活质量及不良反应发生情况。结果A组和B组总有效率分别为72.5%和87.5%,2组近期总有效率比较差异无统计学意义(χ^(2)=2.81,P=0.09)。治疗后B组血清CEA、CA19-9、CA125及VEGF水平低于A组,但2组差异无统计学意义(P>0.05)。A组和B组躯体化、人际关系敏感、强迫症状、焦虑、抑郁、恐怖、敌对、偏执及精神病性评分差异无统计学意义(P>0.05)。B组不良反应总发生率显著低于A组,差异有统计学意义(χ^(2)=42.72,P=0.00)。结论阿帕替尼联合放疗治疗晚期食管癌疗效与同步放化疗相当,两种治疗方案患者预后相近,但阿帕替尼联合放疗能够显著降低患者不良反应发生率,安全性更高。Objective To investigate the therapeutic effects of radiotherapy combined with apatinib as well as simultaneous radiotherapy and chemotherapy on advanced esophageal carcinoma.Methods Eighty patients with advanced esophageal cancer who were treated in our hospital from January 2016 to January 2018 were enrolled in the study,who were divided into group A(n=40)and group B(n=40)according to random digits table.The patients in group A were treated by synchronous radiotherapy and chemotherapy,however,the patients in group B were treated by radiotherapy combined with apatinib.The short-term curative effects,serum tumor marker levels,life quality of patients and adverse reactions were observed and compared between the two groups.Results There was no significant difference in total effective rate between the two groups(P>0.05).After treatment,the serum levels of CEA,CA19-9,CA125 and VEGF in group B were lower than those in group A,but there were no significant differences between the two groups(P>0.05).There were no significant differences in the scores of somatization,interpersonal sensitivity,obsessive compulsive symptoms,anxiety,depression,terror,hostile,paranoia and psychosis between the two groups(P>0.05).Moreover the total incidence rate of adverse reactions in group B was significantly lower than that in group A(P<0.01).Conclusion The efficacy of apatinib combined with radiotherapy in treatment of advanced esophageal cancer is similar to that of synchronous radiotherapy and chemotherapy,and the prognoses of patients treated by the two treatment schemes are similar.However,the apatinib combined with radiotherapy can significantly decrease the incidence of adverse reaction of patients,with better safety.

关 键 词：放疗 化疗 阿帕替尼 晚期食管肿瘤 

分 类 号：R735.1[医药卫生—肿瘤]