基质细胞调节的EMT在肿瘤浸润转移中作用的研究进展  

Research progress on the role of stromal cell-regulated EMT in tumor invasion and metastasis

作　　者：路小超 宗如月 罗新鹏 赵同军 LU Xiao-Chao;ZONG Ru-Yue;LUO Xin-Peng;ZHAO Tong-Jun(Institute of Biophysics,School of Science,Hebei University of Technology,Tianjin 300401,China)

机构地区：[1]河北工业大学理学院生物物理研究所,天津300401

出　　处：《生命科学》2021年第1期95-103,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(11735006)。

摘　　要：恶性肿瘤的浸润转移是肿瘤恶变的主要表现形式之一,而上皮间质转化(epithelial-mesenchymal transition,EMT)是造成肿瘤浸润转移的重要机制。肿瘤细胞通过EMT获得迁移性,进而从原发灶脱离进入血液,随血液循环流动,然后从血管溢出并定植,形成转移灶。EMT的发生与分布在肿瘤周围的基质细胞有密切的关系,受到基质细胞分泌的多种细胞因子的调节。该文就近年来基质细胞调节的EMT在肿瘤浸润转移中作用的研究加以综述,讨论各种基质细胞对EMT诱导的影响,重点讨论肿瘤微环境中对EMT影响较大的几类基质细胞与EMT之间的关系。Invasion and metastasis of malignant tumor is one of the main manifestations of malignant transformation, and epithelial-mesenchymal transition(EMT) is an important mechanism that causes tumor infiltration and metastasis. After acquiring migration through EMT, tumor cells can detach from the primary foci into the blood and flow with the blood circulation. By overflowing from the blood vessels, the tumor cells finally colonize the distant organs and form new metastases. The occurrence of EMT is closely related to the stromal cells distributed around the tumor and is regulated by various cytokines secreted by the stromal cells. In this article, recent studies on the role of stromal cell-regulated EMT in tumor invasion and metastasis are reviewed and the effects of various stromal cells on EMT induction were discussed. Our discussions mainly focused on the relationship between EMT and the types of stromal cells that have a greater impact on EMT process in the tumor microenvironment.

关 键 词：肿瘤微环境 上皮间质转化 基质细胞 细胞因子 

分 类 号：R734.2[医药卫生—肿瘤]