Sperm retrieval rates and clinical outcomes for patients with different causes of azoospermia who undergo microdissection testicular sperm extraction-intracytoplasmic sperm injection  

作　　者：Hong-Liang Zhang Lian-Ming Zhao Jia-Ming Mao De-Feng Liu Wen-Hao Tang Hao-Cheng Lin Li Zhang Ying Lian Kai Hong Hui Jiang 

机构地区：[1]Department of Urology,Peking University Third Hospital,Beijing 100191,China [2]Department of Reproductive Medicine Center,Peking University Third Hospital,Beijing 100191,China [3]Department of Andrology,Peking University Third Hospital,Beijing 100191,China [4]Department of Human Sperm Bank,Peking University Third Hospital,Beijing 100191,China

出　　处：《Asian Journal of Andrology》2021年第1期59-63,共5页亚洲男性学杂志（英文版）

基　　金：This research was sponsored by the National Key Research and Development Project(SQ2018YFC100243);National Key Research and Development Project(2016YFC1000302);National Key Research and Developmental Program of China(2018YFC1003600);Young Scientists Fund of the National NaturalScience Foundation of China(Grant No.81601272);Clinical MedicinePlusX-Young Scholars Project,Peking University(Grant No.2102018237);Beijing Municipal Natural Science Foundation(7182177);National KeyResearch and Development Program of China(Grant No.2017YFC1002001).

摘　　要：The aim of our study was to compare the sperm retrieval rates(SRRs)and clinical outcomes of patients with different causes of azoospermia who underwent microdissection testicular sperm extraction-intracytoplasmic sperm injection(micro-TESE-ICSI).We conducted a retrospective study at the Reproductive Medicine Center of Peking University Third Hospital in Beijing,China,from January 2014 to December 2017.This study examined 769 patients with nonobstructive azoospermia who underwent 347 cycles of micro-TESE-ICSI.Patients with azoospermia were classified into Group A(Klinefelter syndrome,n=284,125 cycles),Group B(azoospermia Y chromosome factor c[AZFc]microdeletion,n=91,64 cycles),Group C(cryptorchidism,n=52,39 cycles),Group D(previous mumps and bilateral orchitis,n=23,23 cycles),and Group E(idiopathic azoospermia,n=319,96 cycles).Clinical characteristics,SRR,embryonic development,and pregnancy outcomes of the patients were compared between all groups.Patients in Group D had the highest and most successful SRR.The average SRR for all patients was 46.0%.The rates of clinical pregnancy,implantation,and live birth in Group D were 78.3%,65.0%,and 74.0%,respectively,which were higher than those in all other groups(P<0.05).Group B patients had the lowest clinical pregnancy,implantation,and live birth rates of all groups(P<0.05).No differences were found in the miscarriage rate or birth defects among the groups(P>0.05).Patients with orchitis had the highest SRR and best clinical outcomes.Although AZFc microdeletion patients had a higher SRR,their clinical outcomes were worse.

关 键 词：AZOOSPERMIA intracytoplasmic sperm injection microdissection testicular sperm extraction pregnancy outcomes sperm retrieval rate 

分 类 号：R697[医药卫生—泌尿科学]