纤溶酶联合阿司匹林治疗对急性脑梗死患者血液黏度和临床疗效的影响  

Effects of fibrinogenase combined with aspirin on blood viscosity and clinical efficacy in patients with acute cerebral infarction

作　　者：侯宇[1] 姜丽杰[1] 薛天宇 于敏[1] Hou Yu;Jiang Lijie;Xue Tianyu;Yu Min(Department of Neurology,the Third People′s Hospital of Dalian City,Dalian 116033,China)

机构地区：[1]大连市第三人民医院神经内科,116033

出　　处：《中国医师进修杂志》2021年第2期149-152,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨纤溶酶联合阿司匹林对急性脑梗死患者的血液黏度和临床疗效的影响。方法收集2016年10月至2020年6月大连市第三人民医院70例轻中度急性脑梗死患者,将患者按照随机数字表法分为对照组和治疗组,各35例。对照组给予阿司匹林口服加上与治疗组等量的0.9%氯化钠静脉滴注,治疗组给予阿司匹林基础上加用纤溶酶静脉滴注。两组均给予管理血糖、血压、稳定斑块及改善循环等对症治疗,均治疗10 d。治疗前后分别对两组进行血液黏度检测和神经功能缺损评分。结果与基线值相比,对照组治疗后血液黏度示所有剪切速率较治疗前略有下降,但差异无统计学意义(P>0.05)。治疗组所有剪切速率均较治疗前下降(P<0.05),且较对照组血液黏度作用效果显著(P<0.05)。治疗组对神经功能的改善优于对照组,治疗组显效率、总有效率均显著高于对照组[34.3%(12/35)比25.7%(9/35)、88.6%(31/35)比71.4%(25/35)]。结论纤溶酶联合阿司匹林治疗急性脑梗死患者,可以安全有效地降低其血液黏度,并改善其临床症状。Objective To investigate the effect of fibrinogenase combined with aspirin on blood viscosity and clinical efficacy in patients with acute cerebral infarction.Methods Senventy patients with mild to moderate acute cerebral infarction from October 2016 to June 2020 were collected from the Third People′s Hospital of Dalian.Patients were divided into control group and treatment group according to the random number table method,with 35 cases in each group.The control group was given oral aspirin plus an intravenous drip of normal saline equal to the treatment group,while the treatment group was given aspirin plus fibrinogenase by intravenous drip.Both groups were given symptomatic treatment such as management of blood glucose,blood pressure,arteriosclerosis plaque stabilization and improvement of circulation for 10 d.Blood viscosity and neurological deficit score were measured before and after treatment.Results Compared with baseline values,WBV showed a slight decrease in all shear rates in the control group after treatment compared with that before treatment,but the difference was not statistically significant(P>0.05).In the treatment group,all shear rates decreased compared with that before treatment(P<0.05),and the effect of WBV was significant compared with that of the control group(P<0.05).The improvement of neurological function in the treatment group was better than that in the control group.The significant efficiency and the total effective rate in the treatment group were significantly higher than those in the control group:34.3%(12/35)vs.25.7%(9/35),88.6%(31/35)vs.71.4%(25/35).Conclusions Fibrinogenase combined with aspirin in the treatment of acute cerebral infarction patients can safely and effectively reduce blood viscosity and improve clinical symptoms.

关 键 词：纤维蛋白溶酶 阿司匹林 梗塞 大脑中动脉 血液黏度 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]