细胞焦亡的分子调控机制及其在肺癌中的研究进展  

Molecular Mechanism of Pyroptosis and Its Role in Lung Cancer

作　　者：徐飞 吴俏兰 陈修保[1] 陈泽涛[1] XU Fei;WU Qiao-lan;CHEN Xiu-bao;CHEN Ze-tao(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Shandong University of Traditional Chinese Medicine,Jinan 250035,China)

机构地区：[1]山东中医药大学附属医院,山东济南250014 [2]山东中医药大学,山东济南250035

出　　处：《肿瘤学杂志》2021年第1期69-73,共5页Journal of Chinese Oncology

基　　金：山东省医药卫生科技发展计划项目(2019WS581);山东中医药大学附属医院人才引进项目(2019)。

摘　　要：细胞焦亡是不同于坏死与凋亡的一种新的程序性细胞死亡方式,炎性小体、Caspase和GASDERMIN家族在焦亡过程中发挥重要作用。细胞焦亡参与肿瘤的发生发展,影响肿瘤细胞的增殖、侵袭与转移,诱导细胞焦亡成为一种潜在的抗肿瘤治疗策略。全文将从GSDMD和Caspase家族探讨焦亡的分子调节机制以及焦亡在肺癌发生发展、治疗中的作用,探索潜在的诊断标志物和治疗靶点,以期为肺癌的诊疗提供新方向与新思路。Pyroptosis is an inflammatory form of programmed cell death,and inflammasome,caspase and GASDERMIN family play an important role in the process of pyroptosis.Abundant studies indicated that pyroptosis participates in the development of tumor,it influences the proliferation,invasion and metastasis of cancer cells.And triggering pyroptosis is regarded as a potential anti-tumor treatment strategy.In this review,we summarizes the molecular mechanism of pyroptosis from the aspect of GSDMD and caspase family and its roles in lung cancer,and also discuss the application of pyroptosis in lung cancer as a potential diagnostic marker and therapeutic target.

关 键 词：肺癌 细胞焦亡 CASPASE家族 

分 类 号：R734.2[医药卫生—肿瘤]