Safety,effectiveness,and cost-effectiveness of ArgusⅡin patients with retinitis pigmentosa:a systematic review  

作　　者：Zakieh Ostad-Ahmadi Amin Daemi Mohammad-Reza Modabberi Ali Mostafaie 

机构地区：[1]Department of Health Management,Policy and Economics,School of Management and Medical Informatics,Kerman University of Medical Sciences,Kerman 7616913555,Iran [2]Health Management and Economics Research Center,Iran University of Medical Sciences,Tehran 1449614535,Iran [3]Student Research Committee,School of Public Health,Shahid Beheshti University of Medical Sciences,Tehran 198353,Iran [4]Iranian Center for Evidence Based Medicine,Tabriz University of Medical Sciences,Tabriz 1983535511,Iran

出　　处：《International Journal of Ophthalmology(English edition)》2021年第2期310-316,共7页国际眼科杂志（英文版）

基　　金：Supported by the National Institute for Health Research(NIHR)of Iran。

摘　　要：AIM:To assess the effectiveness,safety,and costeffectiveness of the Argus II in treatment of the retinitis pigmentosa(RP)patients.METHODS:The Pro Quest,Web of Science,EMBASE,MEDLINE(via Pub Med)were searched using combinations of the keywords of Argus,safety,effectiveness,bionic eye,retinal prosthesis,and RP through March 2018.The retrieved records were screened and then assessed for eligibility.RESULTS:Totally 926 records were retrieved from the searched databases and finally 12 studies included.The RP patients showed improvements in visual function after receiving the prosthesis,compared to the time before the prosthesis or the time it was off.This was measured by square localization,direction of motion,and grating visual acuity tests.No major adverse effect was reported for the Argus II prosthesis itself and/or the surgery to implement it,but the most frequently reported items were hypotony,and conjunctival dehiscence.The incremental cost-effectiveness ratio(ICER)was calculated to be€14603 per qualityadjusted life year(QALY)in UK and$207616 per QALY in Canada.CONCLUSION:The available evidence shows that the Argus II prosthesis in RP patients is effective in improvement of their visual function.Some minor adverse effects are reported for the prosthesis.The cost-effectiveness studies show that the technology is cost-effective only at high levels of willingness-to-pay.

关 键 词：retinitis pigmentosa ArgusⅡ retinal prosthesis EFFECTIVENESS ADVERSE COST-EFFECTIVENESS 

分 类 号：R774.11[医药卫生—眼科]