Corneal stromal mesenchymal stem cells: reconstructing a bioactive cornea and repairing the corneal limbus and stromal microenvironment  

作　　者：Xian-Ning Liu Sheng-Li Mi Yun Chen Yao Wang 

机构地区：[1]Department of Ophthalmology,First Hospital of Xi'an,Shaanxi Institute of Ophthalmology,Shaanxi Provincial Key Lab of Ophthalmology,Clinical Research Center for Ophthalmology Diseases of Shaanxi Province,the First Affiliated Hospital of Northwest University,Xi'an 710002,Shaanxi Province,China [2]Open FIESTA Center,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,Guangdong Province,China [3]Biomanufacturing Engineering Laboratory,Graduate School at Shenzhen,Tsinghua University,Shenzhen 518055,Guangdong Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2021年第3期448-455,共8页国际眼科杂志（英文版）

基　　金：Supported by the National Key R&D Program of China (No.2016YFC1100100);the Key R&D Program of Shaanxi Province (No.2018ZDXM-SF-056);the Health and Family Planning Research Fund Project of Shaanxi Province (No.2016C004);the Key Research and Development Program of Shaanxi Province (No.2019SF-196);the Research Talent Project of Xi’an Municipal Health Commission (No.J201902037)。

摘　　要：Corneal stroma-derived mesenchymal stem cells(CS-MSCs) are mainly distributed in the anterior part of the corneal stroma near the corneal limbal stem cells(LSCs). CS-MSCs are stem cells with self-renewal and multidirectional differentiation potential. A large amount of data confirmed that CS-MSCs can be induced to differentiate into functional keratocytes in vitro, which is the motive force for maintaining corneal transparency and producing a normal corneal stroma. CS-MSCs are also an important component of the limbal microenvironment. Furthermore, they are of great significance in the reconstruction of ocular surface tissue and tissue engineering for active biocornea construction. In this paper, the localization and biological characteristics of CS-MSCs, the use of CS-MSCs to reconstruct a tissue-engineered active biocornea, and the repair of the limbal and matrix microenvironment by CS-MSCs are reviewed, and their application prospects are discussed.

关 键 词：corneal stroma-derived mesenchymal stem cells bioactive cornea corneal limbus tissue-engineered active biocornea stromal microenvironment 

分 类 号：R772.2[医药卫生—眼科]