Intracameral anti-VEGF injection for advanced neovascular glaucoma after vitrectomy with silicone oil tamponade  

作　　者：Ling Bai Forheeti Tariq Yi-Dan He Shu Zhang Feng Wang 

机构地区：[1]Department of Ophthalmology,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710003,Shaanxi Province,China [2]Experimental Teaching Center for Clinical Skills,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710003,Shaanxi Province,China [3]Department of Geriatric Medicine,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710003,Shaanxi Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2021年第3期456-460,共5页国际眼科杂志（英文版）

基　　金：Supported by the Natural Science Foundation of Shaanxi Province (No.2017JM8032)。

摘　　要：AIM: To evaluate the effect of intracameral injection of conbercept for the treatment of advanced neovascular glaucoma(NVG) after vitrectomy with silicone oil tamponade.METHODS: Conbercept 0.5 mg/0.05 m L was injected into the anterior chamber of 5 eyes, which had developed advanced NVG after vitrectomy with silicone oil tamponade. Then, trabeculectomy with mitomycin C and pan-retinal photocoagulation(PRP) or extra-PRP were conducted within 2 d. The follow-up time was 6 mo. Best-corrected visual acuity(BCVA), intraocular pressure(IOP), neovascularization of iris(NVI) were recorded before and after treatment.RESULTS: Within 2 d after injection, IOP control, and NVI regression were optimal for trabeculectomy. Hyphema occurred in one eye in the process of injection. But none of them present hyphema after trabeculectomy. At the end of follow-up time, all eyes had improved BCVA, well-controlled IOP, and completely regressed NVI. CONCLUSION: Intracameral injection of conbercept is safe and effective in the treatment of patients with advanced NVG after vitrectomy with silicone oil tamponade. Within 2 d after injection is the optimal time window for trabeculectomy, which can maximally reduce the risk of perioperative hyphema.

关 键 词：neovascular glaucoma anti-vascular endothelial growth factor therapy conbercept VITRECTOMY silicone oil 

分 类 号：R779.6[医药卫生—眼科] R775[医药卫生—临床医学]