脑源性微粒在头颈部肿瘤放射性脑损伤中对小胶质细胞极化作用的研究进展  

Research progress of brain-derived microparticles on microglia polarization in radiation-induced brain injury of head and neck tumors

作　　者：杜家虞 唐洁[1] 张倩[1] 马晓洁[1] DU Jiayu;TANG Jie;ZHANG Qian

机构地区：[1]川北医学院,四川南充637000

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第1期88-91,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：放射性脑损伤是头颈部恶性肿瘤放射治疗后最严重的并发症之一,常常是不可逆的,并在很大程度上影响了患者的生存期限和生存质量。小胶质细胞是中枢神经系统中先天性免疫系统的主要成分。在放射性脑损伤后的神经炎症中,小胶质细胞发挥了重要的清除和协调修复作用。脑源性微粒(BDMP)是由受损细胞中提取的细胞片段,能够将抗原从母细胞表达到其他细胞中,激活胞内信号通路。近期研究发现BDMP可以与小胶质细胞结合并激活小胶质细胞,促进炎症因子的释放[1-2]。Radiation brain injury(RBI) is one of the complications of radiotherapy for head and neck malignant tumors, which has a serious impact on the prognosis and quality of life of patients. The existence of radiation-induced brain injury not only limits the radiation therapy dose of head and neck malignant tumors, but also restricts the efficacy of tumor patients, and has a serious impact on the prognosis and quality of life of patients. The pathogenesis of radiation-induced brain injury is not yet completely clear, we use various clinical treatment for radiation brain injury patients to alleviate some clinical symptoms, but it cannot effectively reverse the brain injury process. In recent years, with the further exploration of radiation-induced brain injury and the accumulation of clinical experience, studies have found that microglial polarization plays an important role in radiation-induced brain injury, and brain-derived particles can activate microglia. This article reviews the research progress of brain-derived microparticles on the polarization of microglia in radiation-induced brain injury of head and neck tumors.

关 键 词：头颈部肿瘤 放射性脑损伤 小胶质细胞极化 脑源性微粒 

分 类 号：R739.91[医药卫生—肿瘤]