喉癌微环境及代谢特征的研究进展  

Research Progresses on Tumor Microenvironment and Metabolic Characteristics of Laryngeal Carcinoma

作　　者：王皓月 陈建 罗彦波[3] 陈欢[3] 侯宏卫[3] 计敏[1] 胡清源[3] WANG Haoyue;CHEN Jian;LUO Yanbo;CHEN Huan;HOU Hongwei;JI Min;HU Qingyuan(Institute of Optics and Fine Mechanics,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;University of Science and Technology of China,Hefei 230026,China;China National Tobacco Quality Supervision&Test Center,Zhengzhou 450001,China)

机构地区：[1]中国科学院合肥物质科学研究院,安徽光学精密机械研究所,合肥230031 [2]中国科学技术大学,合肥230026 [3]国家烟草质量监督检验中心,郑州450001

出　　处：《中国细胞生物学学报》2021年第2期428-437,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:21277174)资助的课题。

摘　　要：喉癌是一种常见的头颈部恶性肿瘤,但其具体的发病机制尚不明确,是少有的五年生存率呈现下降趋势的一类癌症。越来越多的研究表明,肿瘤微环境中细胞与基质成分的变化、免疫逃逸和代谢重编程等过程对癌症的发生发展具有重要的推动作用。了解喉癌微环境可以为喉癌的发病机制和早期诊断提供新思路,从而制定更好的治疗和预后策略。因此,该文结合喉癌的流行病学现状,对喉癌微环境的组成、在病情发生发展中的作用以及喉癌代谢重编程的具体特征进行了综述。Laryngeal carcinoma is a common kind of head and neck cancer of which pathogenesis is not explicit,and it is one of the few cancers where the five-year survival rate has declined.More and more researches have shown that the changes of cells and stromal components,metabolic reprogramming and immune escape in the tumor microenvironment contribute to the development of cancer.Studying the laryngeal carcinoma microenvironment can add new understanding for the pathogenesis and early diagnosis of laryngeal carcinoma,and develop better treatment and prognosis strategies.Therefore,combined with the epidemiological status of laryngeal carcinoma,this review briefly summarized the composition of tumor microenvironment and its role in the development of laryngeal carcinoma and the specific characteristics of tumor metabolic reprogramming in tumor microenvironment.

关 键 词：喉癌 肿瘤微环境 免疫抑制 代谢特征 

分 类 号：R739.65[医药卫生—肿瘤]