Comparative role of real-world study and traditional randomized controlled trials in head and neck cancer:a literature-based analysis  

作　　者：Guang-Li Zhu Cheng Xu Si-Qi Tang Lei Chen Yan-Ping Mao Ling-Long Tang Guan-Qun Zhou Qing Liu Ying Sun Jun Ma 

机构地区：[1]Department of Radiation Oncology,Sun Yat-Sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangzhou,Guangdong 510060,China

出　　处：《Chinese Medical Journal》2021年第4期489-491,共3页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.81930072);the Key-Area Research and Development Program of Guangdong Province(No.2019B020230002);the Natural Science Foundation of Guangdong Province(No.2017A030312003);the Health&Medical Collaborative Innovation Project of Guangzhou City,China(No.201803040003);the Innovation Team Development Plan of the Ministry of Education(No.IRT_17R110);the Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.B14035)。

摘　　要：To the Editor:In the era of evidence-based medicine,the traditional randomized controlled trials(RCT)is on the top of the pyramid of evidence hierarchy.With well-controlled inclusion and exclusion criteria,randomization,and strict intervention protocol,traditional RCT construct the ideal medical circumstance,under which the causal relationship between the outcome and intervention can be better interpreted.However,it will also make the external validity and generalizability of traditional RCT limited.

关 键 词：RANDOMIZED PYRAMID validity 

分 类 号：R739.91[医药卫生—肿瘤]