Venetoclax联合化疗治疗难治/复发急性髓系白血病8例并文献复习  

Venetoclax combined therapy in 8 patients with refractory/relapsed acute myeloid leukemia and literature review

作　　者：雷芳[1] 费小明[1] 陆益龙[1] 王丽霞[1] 余先球[1] 陈婉如 蒋茜[2] 汤郁[3] LEI Fang;FEI Xiaoming;LU Yilong;WANG Liria;YU Xianqiu;CHEN Wanru;JIANG Qian;TANG Yu(Department of Hematology,Affiliated Hospital of Jiangsu University,Zhenjiang,212001,China;Laboratory,Affiliated Hospital of Jiangsu University,Zhenjiang,212001,China;Department of Rheumatology,Affiliated Hospital of Jiangsu University,Zhenjiang,212001,China)

机构地区：[1]江苏大学附属医院血液科,江苏镇江212001 [2]江苏大学附属医院检验科,江苏镇江212001 [3]江苏大学附属医院风湿科,江苏镇江212001

出　　处：《临床血液学杂志》2021年第1期44-47,共4页Journal of Clinical Hematology

基　　金：国家自然科学基金课题(No:81571582);江苏省卫生健康委科研课题(No:H2018084);江苏省卫生计生委科研课题(No:Z201512);镇江市重点研发计划(社会发展)项目(No:SH2018067)。

摘　　要：目的:评价短疗程Venetoclax(VEN)联合小剂量阿糖胞苷(ara-C)方案在难治/复发急性髓系白血病(AML)患者中的疗效和安全性。方法:报告8例以短疗程VEN+小剂量ara-C方案联合治疗的难治/复发AML患者。VEN使用剂量为200~400 mg QD口服,ara-C 10 mg/m2 Q12 h皮下注射,每疗程用药时间10~14 d。结果:8例患者初始治疗后3例达完全缓解,2例达部分缓解,3例评估为未缓解。治疗过程中发现幼稚单核细胞逐渐增多。发生的不良反应主要是3~4级血液学不良反应。结论:短疗程VEN联合小剂量ara-C方案治疗难治/复发AML患者有较好的有效率和安全性,但对急性单核细胞白血病疗效不佳。Objective:To evaluate the efficacy and safety of short course venetoclax(VEN)combined with low dose cytarabine(ara-C)in patients with refractory or relapsed acute myeloid leukemia(AML). Methods:A report was performed among 8 patients with refractory or relapsed AML treated with short course VEN combination low dose ara-C.VEN was given at 200 to 400 mg orally every day,and ara-C was 10 mg/m2 subcutaneous injection every 12 hours. There were 10 to 14 days for each course of treatment. Results:After initial treatment,3 cases achieved complete response,2 case achieved partial response,and 3 cases had no response.In the course of treatment,we observed that the number of naive monocytes increased.The main adverse events were grade 3 to 4 hematological adverse events.Conclusion:Short course VEN combined with low dose ara-C regimen is effective and safe in the treatment of refractory or relapsed AML patients,but not effective in acute monocytic leukemia.

关 键 词：Venetoclax 小剂量阿糖胞苷 难治/复发急性髓系白血病 

分 类 号：R733.71[医药卫生—肿瘤]