功能性消化不良和胃轻瘫的病理生理学和治疗新进展  

Updates on pathophysiology and treatment of functional dyspepsia and gastroparesis

作　　者：陈建德 成家飞[2] Chen Jiande;Cheng Jiafei(Division of Gastroenterology and Hepatology,University of Michigan,Ann Arbor,Michigan,USA;Department of Gastroenterology,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]密歇根大学医学院消化科,美国密西根州安娜堡市 [2]江苏省中医院消化科,南京210029

出　　处：《中华消化杂志》2021年第1期3-15,共13页Chinese Journal of Digestion

摘　　要：Functional dyspepsia(FD)and gastroparesis are two common functional gastrointestinal diseases,affecting millions of people in both China and around the world.However,treatment options are limited and difficult due to multiple factors involved in their pathophysiologies.Therefore it is critically important to assess and understand pathophysiologies of these diseases before a treatment is given.In this minireview we provide updates on recent development in the pathophysiologies and treatments of FD and gastroparesis.In addition to common abnormalities in gastric accommodation,antral hypomotility and visceral hypersensitivity,FD has recently been reported to display a number of impairment in duodenal functions,such as low-grade inflammation and increased permeability.For gastroparesis,macrophages have recently been reported to play an important role in its pathophysiology.A brief overview on the assessment of pathophysiologies of FD and gastroparesis is also provided;pros and cons of clinically available methodologies as well as emerging methods are discussed.Finally,available treatment options for FD and gastroparesis are presented in this minireview,including authors′opinions on the advantages and disadvantages of each therapy.Potential novel therapies for FD and gastroparesis,especially those associated with Traditional Chinese Medicine,are also introduced and discussed.

关 键 词：Functional dyspepsia GASTROPARESIS Gastrointestinal motility NEUROMODULATION Alternative medicine 

分 类 号：R57[医药卫生—消化系统]