乙型肝炎病毒变异诱发肝细胞癌的分子机制及其研究进展  

Molecular mechanism and research progress of hepatocellular carcinoma induced by hepatitis B virus mutation

作　　者：李子帅 曹广文 Li Zishuai;Cao Guangwen(Department of Epidemiology,Faculty of Naval Medicine,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学海医系流行病学教研室,上海200433

出　　处：《中华流行病学杂志》2021年第1期15-21,共7页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(81673250,81520108021,91529305);国家重点基础研究发展计划(2015CB554000)。

摘　　要：HBV引起的肝细胞癌居我国恶性肿瘤所致死亡原因的第一位。本文从HBV基因组流行病学入手,系统研究了HBV致癌各阶段病毒进化规律及其与宿主遗传因素的交互作用,综合分析了载脂蛋白B mRNA编辑酶催化多肽家族在炎-癌转化中的桥梁作用,进而提出了普适性"癌症进化发育学"理论体系。癌症进化发育学为理解炎症促进癌症发展的机制奠定了理论基础,对多种恶性疾病的特异性预防、预测、早期诊断和靶向治疗具有重要意义。Hepatocellular carcinoma(HCC)caused by hepatitis B virus(HBV)is the first cause of cancer-caused death in China.This study,from the perspective of HBV genomic epidemiology,systematically investigated the evolution of HBV and their interaction with host genetic factors in each stage of HBV carcinogenesis and comprehensively analyzed the role of apolipoprotein B mRNA editing enzyme catalytic polypeptides(APOBEC)family in the inflammation-to-cancer transformation.Based on our findings and related studies,we proposed"cancer evolution and development"(Cancer Evo-Dev)theoretical system suitable for most cancer types.Cancer Evo-Dev lays a theoretical foundation for understanding the mechanism of inflammation to promote the development of cancer,which is of great significance for the specific prevention,prediction,early diagnosis,and targeted therapy of malignant diseases.

关 键 词：肝细胞癌 乙型肝炎病毒 炎症 进化 发育 

分 类 号：R735.7[医药卫生—肿瘤] R512.62[医药卫生—临床医学]