中医药在细胞治疗中的应用现状及未来发展趋势  

Current situation and future development trend of traditional Chinese medicine in cell therapy

作　　者：程金莲[1] 许亚梅[2] 刘彩霞 谭琴 昌晓红[4] 程洪艳[4] 王征旭 游嘉 武立华 童春容 吴迪 王少华 曹彩 马洁 CHENG Jinlian;XU Yamei;LIU Caixia;TAN Qin;CHANG Xiaohong;CHENG Hongyan;WANG Zhengxu;YOU Jia;WU Lihua;TONG Chunrong;WU Di;WANG Shaohua;CAO Cai;MA Jie(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Center of Biotherapy,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Peking University People's Hospital,Beijing 100044,China;Seventh Medical Center of Chinese PLA General Hospital,Beijing 100700,China;Beijing Boren Hospital,GoBroad Medical Institute of Hematology,GoBroad Healthcare Group,Beijing 100070,China;Zhongguancun Jiutai Good Clinical Practice Union,Beijing 100101,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]北京中医药大学东直门医院,北京100700 [3]北京医院生物治疗中心,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [4]北京大学人民医院,北京100044 [5]中国人民解放军总医院第七医学中心,北京100700 [6]高博医学(血液病)北京研究中心北京博仁医院,北京100070 [7]中关村玖泰药物临床试验技术创新联盟,北京100101

出　　处：《药物评价研究》2021年第2期265-272,共8页Drug Evaluation Research

基　　金：国家科技重大专项课题——重大新药创制(2016ZX09101094);北京市科委企业技术创新平台建设(Z181100000518028)。

摘　　要：细胞治疗作为新兴的现代生物医学技术,促进了以精准医学和系统生物学为代表的治疗变革,也不断地与中医关于生命认识的整体观和"天人合一"的思维接近。细胞治疗为肿瘤等多种疾病的治疗提供了新的策略,但其不良反应和应用局限制约了其在临床上的广泛应用。中医药与细胞治疗联合使用,发挥协同作用,在提高细胞治疗疗效、减轻毒副作用方面已经做了一些探索和尝试。概述中医药在免疫细胞治疗、干细胞治疗和基因修饰体细胞治疗中的应用现状,初步探讨中医药联合细胞治疗在未来的发展趋势。As an emerging modern biomedical technology,cell therapy has promoted the therapeutic revolution represented by precision medicine and systematic biology,and is also close to the concept of the holistic view of life understanding and"harmony between man and nature"in traditional Chinese medicine.Cell therapy provides a new strategy for the treatment of many diseases such as tumors,but its adverse reactions and application limitations restrict its wide application in clinic.Combined use of traditional Chinese medicine and cell therapy plays a synergistic role,and some explorations and attempts have been made to improve the efficacy of cell therapy and reduce the toxic and side effects.This paper summarizes the application of TCM in immune cell therapy,stem cell therapy and genetically modified somatic cell therapy,and discusses the development trend of TCM combined cell therapy in the future.

关 键 词：中医药 细胞治疗 免疫细胞治疗 干细胞治疗 基因修饰体细胞治疗 发展趋势 

分 类 号：R926[医药卫生—药学]