Chiral Imidazoline Ligands and Their Applications in Metal-Catalyzed Asymmetric Synthesis  

作　　者：Jiajing Li Bing Yu Zhan Lu 

机构地区：[1]Department of Chemistry,Zhejiang University,Hangzhou,Zhejiang,310058 China [2]College of Chemistry,Zhengzhou University,Zhengzhou,Henan,450001 China

出　　处：《Chinese Journal of Chemistry》2021年第2期488-514,共27页中国化学（英文版）

基　　金：Financial support was provided by NSFC(21922107 and 21772171);Zhejiang Provincial Natural Science Foundation of China(LR19B020001);Center of Chemistry for Frontier Technologies,and the Fundamental Research Funds for the Central Universities(2019ONA3008).

摘　　要：As a structural analog of oxazoline,imidazoline(4,5-dihydroimidazole)has received much attention in the rational design of chiral ligands.The additional N-substituent provides broader space for fine-tuning of electronic and steric effects,and it offers a good handle for immobilizing onto solid supports.In the past decades,imidazoline ring has emerged as a powerful candidate for the design of chiral nitrogen-containing ligands,as well as a significant alternative for oxazoline ring.Various chiral imidazoline ligands have been designed and utilized in asymmetric organic reactions.These new catalysts can not only be applied in classical reactions,but also be employed to develop new organic reactions with high enantioselectivities.This review provides an overview of chiral imidazoline ligands.Their applications in asymmetric synthesis are also summarized.

关 键 词：N ligands Asymmetric catalysis Chiral imidazoline ENANTIOSELECTIVITY Metal catalysis 

分 类 号：O62[理学—有机化学]