胃癌癌相关成纤维细胞研究进展  

Research progress of cancer-associated fibroblasts in gastric cancer

作　　者：郭嘉欣 徐远义[1] Guo Jia-Xin;Xu Yuan-Yi(Department of Pathology,School of Basic Medicine,Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学基础医学院病理系,银川750004

出　　处：《解放军医学杂志》2021年第3期306-310,共5页Medical Journal of Chinese People's Liberation Army

基　　金：宁夏回族自治区重点研发计划(2019BEG03007,2018BEG03010);宁夏自然科学基金(2020AAC03184)。

摘　　要：胃癌是全球发病率第五、病死率第三的癌症。在中国,胃癌患者就诊时多为晚期且预后较差。癌症进展不仅取决于癌细胞自身,还取决于其所处的环境即肿瘤微环境的生理状态与构成改变,其中癌相关成纤维细胞作为肿瘤微环境中重要的细胞类型,在癌症进展中发挥着重要作用。该文阐述癌相关成纤维细胞的来源和分型,以及对胃癌侵袭转移、生长、血管生成、基质重塑、免疫调节及抑癌等方面作用的研究进展,总结靶向胃癌中癌相关成纤维细胞的相关抗肿瘤策略,以期为癌相关成纤维细胞应用于胃癌的靶向治疗提供更多信息。Gastric cancer is the fifth leading incidence and the third leading cause of death in the world.Gastric cancer patients in China are often in advanced stages and have a poor prognosis.Cancer progression depends not only on the cancer cells themselves,but also on the physiological state and composition of the tumor microenvironment in which they are located.Cancerassociated fibroblasts as the major cell type in the tumor microenvironment played an important role in cancer progression.This paper mainly expounds the origin and classification of cancer-associated fibroblasts,and its research progress on gastric cancer invasion and metastasis,growth,angiogenesis,matrix remodeling,immunomodulation and cancer suppression,and summarizes the relevant anti-tumor strategies by targeting cancer-associated fibroblasts in gastric cancer,to provide more information for use of cancer-associated fibroblasts in targeted therapy of gastric cancer.

关 键 词：胃癌 癌相关成纤维细胞 肿瘤微环境 靶向策略 

分 类 号：R735.2[医药卫生—肿瘤]