生血益髓汤防治TP方案化疗所致骨髓抑制的临床效果  

Clinical effect on the prevention and treatment of bone marrow suppression induced by TP chemotherapy with Shengxue Yisui decoction

作　　者：李爽 于洁 米硕 LI Shuang;YU Jie;MI Shuo(Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院,北京101300

出　　处：《现代肿瘤医学》2021年第8期1386-1390,共5页Journal of Modern Oncology

基　　金：北京市科学技术计划项目(编号:20180253057)。

摘　　要：目的:观察生血益髓汤对防治TP方案化疗所致骨髓抑制的临床效果。方法:纳入本院2017年1月至2019年6月接受TP方案化疗的肿瘤患者共60例,随机数字法将其分为观察组及对照组各30例;对照组实施TP化疗方案,观察组实施TP化疗方案+生血益髓汤;比较两组患者化疗后骨髓抑制、KPS等临床指标。结果:化疗前两组患者外周血血象无明显差异(P>0.05);观察组患者化疗后7天与化疗后14天的外周血白细胞计数及血小板计数下降程度均小于对照组,差异均有统计学意义(P<0.05);两组患者血红蛋白含量在化疗后7天与化疗后14天均稍有下降,但差异无统计学意义(P>0.05);对照组及观察组患者骨髓抑制总体发生率分别为92.9%及79.3%,两组差异无统计学意义(P>0.05);对照组Ⅲ-Ⅳ度骨髓抑制发生率(39.3%)明显高于观察组(13.8%),差异有统计学意义(P<0.05);对照组在治疗期间rhG-CSF及IL-11使用量较观察组大,其中rhG-CSF使用量差异有统计学意义(P<0.05);对照组患者治疗后KPS稳定率明显低于观察组(57.1%vs 82.8%),差异有统计学意义(P<0.05)。结论:生血益髓汤对防治TP方案化疗所致骨髓抑制的效果较好,并可有效减轻化疗毒副反应、提高肿瘤患者化疗后生活质量。Objective:To study the clinical effect of Shengxue Yisui Decoction on prevention and treatment of myelosuppression induced by TP chemotherapy.Methods:A total of 60 cancer patients who received TP chemotherapy in our hospital from January 2017 to June 2019.They were divided into observation group and control group with 30 cases each by random number method.The patients of the control group were given TP chemotherapy,while the observation group were given TP chemotherapy with Shengxue Yisui Decoction.The clinical indexes of myelosuppression and KPS after chemotherapy were compared between the two groups.Results:There was no significant difference in peripheral blood hemogram between the two groups before chemotherapy(P>0.05).The decrease of peripheral blood leukocyte count and platelet count in the observation group was less than that in the control group 7 days after chemotherapy and 14 days after chemotherapy(P<0.05).The hemoglobin content in the two groups was slightly decreased in 7 days after chemotherapy and 14 days after chemotherapy,but the difference was not statistically significant(P>0.05).The overall incidence of bone marrow depression in the control group and the observation group was 92.9%and 79.3%,respectively,with no significant difference between the two groups(P>0.05).The incidence of grade Ⅲ-Ⅳ bone marrow depression in the control group(39.3%)was significantly higher than that in the observation group(13.8%)(P<0.05).The use of rhG-CSF and IL-11 in the control group was more than that in the observation group during the treatment period,and the use of rhG-CSF had significant difference(P<0.05).The stability rate of KPS in the control group was significantly lower than that in the observation group(57.1%vs 82.8%,P<0.05).Conclusion:Shengxue Yisui Decoction is effective in preventing and treating myelosuppression caused by TP chemotherapy,and can effectively reduce the toxicity and side effects of chemotherapy and improve the quality of life of cancer patients after chemotherapy.

关 键 词：化疗 骨髓抑制 毒副反应 防治 

分 类 号：R730.5[医药卫生—肿瘤]