环状RNA在胶质瘤中的研究进展  

Research progress of circular RNA in glioma

作　　者：赵羲和[1] 刘磊[2] 邹华伟[1] ZHAO Xihe;LIU Lei;ZOU Huawei(Department of Clinical Oncology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China;Department of General Surgery,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院肿瘤科,辽宁沈阳110004 [2]中国医科大学附属盛京医院普外科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2021年第8期1446-1449,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81802760,81702402);辽宁省科技厅项目(编号:20170520027);盛京医院“345人才工程计划”。

摘　　要：恶性胶质瘤是中枢神经系统常见的肿瘤之一,恶性度高、难以安全切除,即使进行手术联合放化疗的综合治疗,仍有90%患者复发。目前胶质瘤的发病机制仍不明确。其在早期诊断以及长期有效的治疗上仍然面临着严峻的挑战。近年来非编码RNA备受关注。环状RNA(circular RNA,circRNA)的发现,极大地补充了传统基因表达理论。circRNA的表达高,表达呈时空特异性及物种间保守性,其参与了多种肿瘤的发生,调控肿瘤发展。因此,本文就circRNA在胶质瘤中的表达、诊断、预后价值以及发生发展过程中的作用展开综述,以期为胶质瘤的早期诊治寻找新的靶点。Malignant glioma is one of the most common tumors in central nervous system.It is difficult to be safely removed due to the high malignancy.90%of the patients will still relapse even undergo the comprehensive treatment of surgery combined with radiotherapy and chemotherapy.At present,the pathogenesis of glioma is still unclear.Severe challenges still exist in early stage diagnosis and long-term treatment.Recently,more and more attention has been paid to noncoding RNA.The discovery of circular RNA(circRNA)greatly complements the traditional gene expression theory.The expression of circRNA is high,spatiotemporal specific and species conservative.It participates in the occurrence of many kinds of tumors and regulates the development of tumors.Therefore,this article reviews the expression,diagnosis,prognostic value and development mechanism of circRNA in gliomas in order to find new targets for early diagnosis and treatment of gliomas.

关 键 词：circRNA MICRORNA 胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]