自噬及自噬调节剂在脑缺血中的研究进展  

Advances in the regulation of autophagy and its regulators in cerebral ischemia

作　　者：王恺迪 张丽梅 黎晓[2] WANG Kai-di;ZHANG Li-mei;LI Xiao(Gannan Medical University;School of Basic Medicine of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院基础医学院,江西赣州341000

出　　处：《赣南医学院学报》2021年第2期109-114,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(No.31760290);心脑血管疾病防治教育部重点实验室开放课题(No.XN201923);赣南医学院研究生创新项目(YC2020-S620)。

摘　　要：自噬是一种重要的生物学机制,参与和调节许多与组织细胞生长和分化相关的过程。脑缺血时,脑组织中神经元、胶质细胞或脑微血管细胞中的自噬都可被激活,但自噬激活后所起的作用却存在争议。目前认为,自噬在脑缺血中扮演着“双刃剑”的作用,因此,通过自噬调节剂来调节自噬平衡或许可成为脑缺血防治的关键。多数观点认为,自噬调节剂可能是通过增强线粒体功能和减弱损伤性自噬过程等路径实现调控作用,且作用机制纷繁复杂。为了更好地了解自噬与自噬调节剂在脑缺血中的作用及机制,本文就其研究现状和未来方向作一综述,以期为研究脑缺血疾病自噬机制的相关人员提供参考。Autophagy is an important biological mechanism that participates in and regulates many processes associated with tissue cell growth and differentiation.A lot of evidence shows that the neuron in brain tissue,glial cell or brain microvascular cell autophagy will be activated when cerebral ischemia.However,the role of autophagy activation is controversial.At present,autophagy is considered to play a"double-edged sword"role,Therefore,regulating autophagy balance through autophagy regulator may be the key to the prevention and treatment of cerebral ischemia.As a result,the research on autophagy regulator also emerged.The majority view is that autophagy regulators are likely by enhancing mitochondrial function and weakening damaging autophagy process.In order to better understand the role and mechanism of autophagy and autophagy regulators in cerebral ischemia,this paper reviews the research status and future directions of autophagy regulators,hoping to provide reference for those who study the autophagy mechanism in cerebral ischemia.

关 键 词：自噬 自噬调节剂 脑缺血 

分 类 号：R741.02[医药卫生—神经病学与精神病学]