TRIM32与相关疾病的研究进展  

Research Progress of TRIM32 and Related Diseases

作　　者：张晗 孟宪勇[2] 赵学萍 董晓华[1] ZHANG Han;MENG Xian-yong;ZHAO Xue-ping;DONG Xiao-hua(Hebei Key Laboratory of Neuropharmacology,Hebei North University,Zhangjiakou,Hebei 075000,China;The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院河北省神经药理学重点实验室,河北张家口075000 [2]河北北方学院附属第一医院,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2021年第4期59-64,共6页Journal of Hebei North University:Natural Science Edition

基　　金：河北省自然基金面上项目(No.H2019405081);河北省教育厅重点课题(No.ZD2018231);河北省卫生厅资助项目(No.2016035);河北北方学院资助项目(No.YB2018001);河北北方学院硕士研究生创新资助项目。

摘　　要：三结构域蛋白(tripartite motif protein,TRIM)家族是一个结构保守、快速进化的家族,在细胞生长、凋亡、免疫等方面发挥重要作用。隶属于TRIM家族的TRIM32是一种泛素连接酶(ubiquitin ligase enzyme,E3),也称底物识别因子(substrate recognition factor)。目前对TRIM32的研究较少,已知的特异性底物有actin、ABI2、c-Myc、dysbindin和PIASy。TRIM32异常与多种疾病密切相关,综述了TRIM32在抗病毒、抗肿瘤、肢带肌萎缩症以及神经精神系统疾病中的作用。Tripartite motif(TRIM)family is a conserved and rapidly evolving family,which plays an important role in cell growth,apoptosis and immunity.Trim32,a member of the trim family,is a ubiquitin ligase(E3),also known as a substrate recognition factor.At present,there are few studies on TRIM32,and the known specific substrates are actin、ABI2、c-Myc、dysbindin and PIASy.The abnormality of TRIM 32 is closely related to many diseases.This paper reviews the role of TRIM32 in antivirus,antitumor,limb-girdle muscular dystrophy and neuropsychiatric diseases.

关 键 词：TRIM32 泛素化 抗病毒 抗肿瘤 肢带肌萎缩症 

分 类 号：R737[医药卫生—肿瘤]