谷胱甘肽过氧化物酶GPX4在铁死亡中的作用与机制研究进展  

Research progress on the role and mechanism of GPX4 in ferroptosis

作　　者：程峰[1] 张庸 王祥 窦晋涛 吴志浩[1,5] CHENG Feng;ZHANG Yong;WANG Xiang;DOU Jintao;WU Zhihao(Tumor Microenvironment Research Laboratory,Wannan Medical College,Anhui Wuhu 241001,China;School of Clinical Medicine,Wannan Medical College,Anhui Wuhu 241001,China;School of Laboratory Medicine,Wannan Medical College,Anhui Wuhu 241001,China;School of Anesthesia,Wannan Medical College,Anhui Wuhu 241001,China;School of Basic Medicine,Wannan Medical College,Anhui Wuhu 241001,China)

机构地区：[1]皖南医学院肿瘤微环境研究室,安徽芜湖241001 [2]皖南医学院临床医学院,安徽芜湖241001 [3]皖南医学院检验学院,安徽芜湖241001 [4]皖南医学院麻醉学院,安徽芜湖241001 [5]皖南医学院基础医学院,安徽芜湖241001

出　　处：《现代肿瘤医学》2021年第7期1254-1258,共5页Journal of Modern Oncology

基　　金：国家自然科学基金面上项目(编号:81872371);安徽省自然科学基金面上项目(编号:1708085MH203);分子肿瘤学国家重点实验室开放课题(编号:SKL-KF-2019-11)。

摘　　要：谷胱甘肽过氧化物酶4(GPX4)是一种能够特异性催化谷胱甘肽将脂质过氧化物转化为类脂醇的硒蛋白,它在调节细胞铁死亡方面发挥着重要的作用。本文将对GPX4的蛋白结构、分子作用机制及其表达调控进行介绍,对其在铁死亡中的功能以及在癌症等疾病中的应用进行系统综述,对未来存在的问题进行了分析与展望。Glutathione peroxidase GPX4 is a selenoprotein that can specifically catalyze the conversion of glutathione to lipid peroxides to lipid alcohols.It plays an important role in regulating ferroptosis in cells.This article will introduce the protein structure,molecular action mechanism and expression regulation of GPX4,systematically review its function in ferroptosis and its application in cancer and other diseases.To analyze and prospect the future problems.

关 键 词：GPX4 铁死亡 脂质过氧化 癌症 

分 类 号：R730[医药卫生—肿瘤]