癫痫动物模型的研究进展  

Animal models of seizures and epilepsiesy

作　　者：董博思 邱湘苗 赖婉琳 李宛凌 彭安娇[1] 陈蕾[1] DONG Bosi;QIU Xiangmiao;LAI Wanlin;LI Wanling;PENG Anjiao;CHEN Lei(Department of Neurology,West China Hospital of Sichuan University,Chengdu 610041)

机构地区：[1]四川大学华西医院神经内科,成都610041

出　　处：《中国比较医学杂志》2021年第3期128-138,共11页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金面上项目(81871018)。

摘　　要：癫痫是一种常见的神经疾病,但我们对于其病因知之甚少,因此很难找到有效的治疗方法。在过去的30年里,癫痫动物模型在研究癫痫发生机制和确定潜在治疗药物等方面都起着至关重要的作用。但迄今为止,还没有任何一个理想的单一模型被证实可用于识别潜在的药物和充分解释癫痫的发生原因。本综述对目前制备癫痫动物模型的方法及优化方案进行总结,为癫痫模型的选择提供参考,并提供了未来一些癫痫模型制备方向的见解。Epilepsy is a common neurological disorder,with but little acknowledge ofis known about its causes,thus leading tomaking it difficulty into finding an effective therapyies.Over the last 30 years,experimental models of epilepsiesy have contributed greatly in to improving our understanding of epilepsy and identification of potential therapeutic agents for epilepsy.However,there is notno one"ideal"animal model exists for the discoverying of new antiepileptic drugs and or fully explaining epileptogenesis.This paper provides a review of the research of using experimental models of epilepsiesy and provides new some insights on the futureand direction of for the establishment ofing epileptic models of epilepsy.

关 键 词：癫痫 动物模型 点燃模型 遗传性模型 

分 类 号：R-33[医药卫生]