Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes  

作　　者：Katie EOlagaray Barry J.Bradford Lorraine M.Sordillo Jeffery C.Gandy Laman K.Mamedova Turner H.Swartz Trey D.Jackson Emma K.Persoon Caitlin S.Shugart Curtis R.Youngs 

机构地区：[1]Department of Animal Sciences and Industry,Kansas State University,Manhattan 66506,USA [2]College of Veterinary Medicine,Michigan State University,2265K Anthony Hall,East Lansing,MI 48824-1225,USA [3]Department of Animal Science,Iowa State University,Ames,IA,USA.

出　　处：《Journal of Animal Science and Biotechnology》2020年第4期1047-1060,共14页畜牧与生物技术杂志（英文版）

基　　金：funded by a Let’s Grow grant through the American Sheep Industry。

摘　　要：Background: Postpartum inflammation is a natural and necessary response;however, a dysfunctional inflammatory response can be detrimental to animal productivity. The objective of this study was to determine the effects of a non-steroidal anti-inflammatory drug(meloxicam) on ewe postpartum inflammatory response, ewe plasma polyunsaturated fatty acid and oxylipid concentrations, and lamb growth.Results: After lambing, 36 Hampshire and Hampshire × Suffolk ewes were sequentially assigned within type of birth to control(n = 17) or meloxicam orally administered on d 1 and 4 of lactation(MEL;90 mg, n = 19). Milk and blood samples were collected on d 1(prior to treatment) and d 4. Milk glucose-6-phosphate was not affected by MEL. Plasma haptoglobin(Hp) concentrations were less for MEL ewes;control ewes with greater d 1 Hp concentrations had elevated Hp on d 4, but this was not the case for MEL-treated ewes. Treatment with MEL increased plasma arachidonic acid concentration by more than 4-fold in ewes rearing singles but decreased concentrations of 9,10-dihydroxyoctadecenoic acid, prostaglandin F2α, 8-iso-prostaglandin E2, and 8,9-dihydroxyeicosatetraenoic acid. Nine oxylipids in plasma had interactions of treatment with d 1 Hp concentration,all of which revealed positive associations between d 1 Hp and d 4 oxylipid concentrations for CON, but neutral or negative relationships for MEL. MEL decreased 13-hydroxyoctadecadienoic acid:13-oxooctadecadienoic acid ratio and tended to increase 9-hydroxyoctadecadienoic acid:9-oxooctadecadienoic acid ratio(both dependent on d 1 values), indicating progressive metabolism of linoleic acid-derived oxylipids occurred by enzymatic oxidation after MEL treatment. Meloxicam reduced oxylipids generated across oxygenation pathways, potentially due to an improved redox state.Conclusions: Postpartum MEL treatment of ewes decreased plasma concentrations of Hp and several oxylipids,with the greatest impact in ewes with biomarkers reflecting a greater inflammatory state before treatment. Antiinf

关 键 词：EICOSANOID Inflammation LACTATION Nonsteroidal anti-inflammatory drug Sheep 

分 类 号：S826.5[农业科学—畜牧学]