内质网氧化还原蛋白1及其与肿瘤关系的研究进展  

Research progress of endoplasmic reticulum oxidoreductin ERO1 and its relationship with tumor

作　　者：吴敏(综述)[1] 黄尤光(审校)[1] WU Min;HUANG Youguang(Cancer Research Institute,the Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital,Kunming,Yunnan 650118,China)

机构地区：[1]昆明医科大学第三附属医院/云南省肿瘤医院肿瘤研究所,650118

出　　处：《重庆医学》2021年第6期1048-1052,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81660417)。

摘　　要：内质网氧化还原蛋白1(ERO1)是细胞蛋白折叠的关键分子,在细胞正常生理活动中发挥重要的作用。近年研究发现,ERO1在多种类型的肿瘤组织和细胞系中高表达,其表达水平与肿瘤的发生发展及患者预后密切相关。本文就ERO1的生物学特性及其与肿瘤关系的研究进展进行综述,展望ERO1作为临床防治肿瘤的一个新靶点。Endoplasmic reticulum redox protein 1(ERO1)is a key moleculear in cell protein folding and plays an important role in the normal physiological activities of cells.Recent studies have found that ERO1 was highly expressed in various types of tumor tissues and cell lines,and its expression level was closely related to the occurrence and development of tumors and the prognosis of patients.This article reviewed the research progress of the biological characteristics of ERO1 and its relationship with tumors,and prospected that ERO1 intervention could be used as a new intervention strategy for clinical prevention and treatment of tumors.

关 键 词：内质网氧化还原蛋白1 肿瘤 恶性生物学行为 作用机制 

分 类 号：R730.2[医药卫生—肿瘤]